Animal Cell Technology: Basic & Applied Aspects

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Animal cell technology is a growing discipline of cell biology which aims not only to understand structures, functions and behaviours of differentiated animal cells but also to ascertain their abilities to be used for industrial and medical purposes. The goal of animal cell technology includes accomplishments of clonal expansion of differentiated cells with useful ability, optimization of their culture conditions, modulation of their ability for production of medically and pharmaceutically-important proteins, and the application of animal cells to gene therapy and artificial organs. This volume gives the readers a complete review of the present state of the art in Japan. The proceedings should be useful for cell biologists, biochemists, molecular biologists, immunologists, biochemical engineers and other disciplines related to animal cell culture, working either in academic environments or in industries of biotechnology and pharmacy.

Published : Thursday, January 01, 1998
Reading/s : 6
Licence : All rights reserved
EAN13 : 0306468654
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Contents
Preface
Symposium 1
Role of Heparan Sulfate Proteoglycan in Cell Growth and Differentiation
THE FUNCTION OF DALLY, A DROSOPHILA GLYPICAN, I N DPP SIGNALING Nakato, H., Izumi, S. and Selleck, S. B.
Symposium 2
Glycoengineering
NOVEL FORMS OF PROTEIN O-GLYCOSYLATION Haltiwanger, R. S.
SYNTHESIS OF GLYCOCONJUGATES: THEIR USE TO STUDY THE INTRACELLU-LAR TRAFFIC OF ENDOGENOUS LECTINS AND TO DELIVER OLIGONUCLEOTIDES AND GENES Monsigny, M., Quetard, C., Bourgerie, S., Carriere, V., Duverger, E., Altemayer, V., Pichon, C., Mayer, R., Midoux, P. and Roche, A. C.
OLIGO/POLYSIALIC ACIDS IN SEA URCHIN: A DEVELOPMENTALLY REGULATED SEA URCHIN POLYSIALYLTRANSFERASE Cho,J. W.
CLONING AND APPLICATION OF GLYCOSYLTRANSFERASES INVOLVED IN THE BIOSYNTHESIS OF SELECTIN LIGANDS Sasaki, K., Kurata-Miura, K., Hasegawa, M. and Nishi, T.
INDUCTION OF GANGLIOSIDE BIOSYNTHESIS, NEURITE OUTGROWTH AND FUNCTIONAL SYNAPSE FORMATION BY A SYNTHETIC CERAMIDE ANALOG Inokuchi, J.
Symposium 3
Artificial Organ and Cell Therapy
HUMAN CYTOTOXIC T LYMPHOCYTES FOR TUMOR THERAPY Ohno, T.
ORGANOID FORMATION WITH BRANCHED CAPILLARY-LIKE NETWORKS Takezawa, T. and Yoshizato, K.
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xiii
1
7
15
23
27
33
37
43
vi
Symposium 4
Immunological Manipulation
CYTOTOXIC ANTIBODIES TO ADIPOCYTES: AGRICULTURAL AND CLINICAL POTENTIAL K e s t i n , S., F u tter, C. E., Tonner, E., Kennedy, R.., B u t t e r w i t h , S., R h i n d , S. M ., G r i f f i n , H., Cryer, A. and Flint, D. J.
IMMUNOLOGICAL MANIPULATION OF LACTATION W ilde, C. J., Addey, C. V. P., Cam pbell, F. M. and Peaker, M.
LIG H T C H A I N SH IFTIN G -C H A R A C TER IZA TIO N OF LIGHT C H A I N REPLACE-MENT IN H U M A N PLASMA B CELLS Haruta, H., Tachibana, H. and Yamada, K.
Symposium 5
DT40 Cells as a System of Homologous Gene Recombination
CREATION OF HYBRIDOMAS FROM MICE EXPRESSING HUMAN ANTIBODY BY INTRODUCTION OF A H U M A N CHROMOSOME Yoshida, H., Tomizuka, K., Uejima, H., Satoh, K., Ohguma, A., Oshimura, M. and Ishida, I..
Symposium 6
Transgenic Livestock
TRANSGENICALLY PRODUCED BIOPHARMACEUTICALS Young, M. W.
OPTIMISATION OF TRANSGENE EXPRESSION IN THE MAMMARY GLAND W hitelaw, C. B. A. and Clark, A. J.
Symposium 7
Transgenic Fish: Standardization of Technology in the Model System and Aquaculture
INTRODUCTORY R E M A R K : A DECADE OF TRANSGENIC FISH Ozato, K.
TRANSGENIC MEDAKA FISH STRAINS WITH LIGHTENED BODY COLOR AND BIOLUMINESCENCE K inoshita, M.
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55
63
69
75
81
91
93
TRANSGENIC ZEBRAFISH AS A BIOSENSOR Yamashita, M.
TRANSGENIC SALMONFOR AQUACULTURE Fletcher, G. L. and Hew, C. L.
Symposium 8
Growth, Immortality and Death of Cells in Culture: Present and Future Impact for the Development of Health Care Products
FOOD COMPONENTS WITH POTENTIALITIES TO SUPPRESS PROLIFERATION A N D INVASION OF CANCER CELLS Yagasaki, K. and Miura, Y.
DEVELOPMENT OF THROMBOPOIETIN: ITS STRUCTURE AND FUNCTION O h g am i, K.
Symposium 9
Gene Transfer to Cells and Tissues of Living Animals: Applica-tion to Production and Therapeutics
B A C U L O V I R U S NOT ONLY AS A N INSECT EX PRESSIO N VECTOR BUT AS A G EN E TRANSFER VECTOR Kobayashi, J.
IN VIVOELECTROPORATION: MANIPULATIONS OF  GENE CELLS TO WHOLE BODY OF LIVING ANIMALS Muramatsu, T.
Oral Session
Cell Culture for Assessment of Physiologically Functional Substances
IN VITRO STIMULATION OF TUMOR NECROSIS FACTOR PRODUCTION FROM RAT SPLENOCYTES BY CABBAGE EXTRACT K om atsu, W., M iura, Y. and Yagasaki, K .
EFFECTS OF GREEN, OOLONG AND BLACK TEAS AND RELATED COMPONENTS ON PROLIFERATION A N D IN V A S IO N OF HEPATOMA CELLS Zhang, G. Y., Miura, Y. and Yagasaki, K.
Expression of Recombinant Animal Genes in Cultured Animal Cells
vii
97
101
107
113
119
125
131
135
viii
M I L K SECRETION I N CULTURED M A M M A R Y EPITHELIAL CELLS Blatchford, D. R., Wilde, C. J., Matsuda, T. and Aoki, N.
HYPERTHERMIC I N D U C T I O N OF GENE EXPRESSION U S I N G STRESS I N D U C I B L E PROMOTER Bouhon, I. A., Ito, A., Shinkai, M., Honda, H. and Kobayashi, T.
Cell Culture Engineering
E N H A N C E M E N T OF PRODUCTIVITY OF RECOMBINANT BY LOW TEMPERATURE CULTURE Furukawa, K. and Ohsuye, K.
ENZYME
DIALYSIS-FIXED-BED CULTURES FOR HIGHLY EFFICIENT PRODUCTION OF CHIMERIC FAB-FRAGMENTS WITH TRANSFECTOMA CELLS IN PROTEIN-FREE M E D IU M Pörtner, R., Lüdemann, I., Reher, K., Neumaier, M. and Märkl, H.
Cost Performance for Producing Biochemicals
MONITORING DRUG EFFECTS ON H U M A N PRIMARY TISSUES UTILIZING FIBRE OTICAL SENSORS Maerz, H.
Establishment of Functional Cell Lines for Production of Biologicals
I N C R E A S I N G ANTIBODY PRODUCTION BY SUPPRESSING CELL PROLIFERA-TION WITH CONTROLLABLE EXPRESSION OF CYCLIN INHIBITOR P21 AND P27 Fujita, T., Terada, S., Ueda, H., Nagamune, T. and Suzuki, E.
ESTABLISHMENT OF AN APOPTOSIS-RESISTANT AND GROWTH-CONTROL-LABLE CELL LINE BY TRANSFECTING WITH INDUCIBLE ANTISENSE c-JUN GENE Kim, Y. H., Iida, T., Prochownik, E. V. and Suzuki, E.
IMPROVEMENT OF CELL SURVIVAL BY INHIBITION OF CASPASES PLAYING KEY ROLES IN APOPTOSIS Terada, S., Yata, T., Fukuoka, K., Aizawa, H., Fujita, T., Nagamune, T. and Suzuki, E.
Application of Human Monoclonal Antibody
IN VITROPERIPHERAL BLOOD LYMPHOCYTESU M A N OF H  IMMUNIZATION WITH 14-16 kDa RICE ALLERGEN PROTEINS Ichikawa, A., Katakura, Y., Teruya, K., Hashizume, S., Matsuda, T. and Shirahata, S.
141
147
153
159
165
171
177
185
191
Cell Characterization and Validation
OPTIONS TO ELIMINATE ANIMAL-DERIVED COMPONENTS OF CELL CULTURE MEDIA Jayme, D. W. and Smith, S. R.
CHARACTERIZATION OF THE SUBPOPULATIONS OF RAT ASCITES HEPATOMA AH109A CELLS WITH DIFFERENT INVASIVE AND METASTATIC ACTIVITIES Miura, Y., Miyauchi, M., Kubota, K., Li, Q., Tachikawa, H., Fujimoto, D. and Yagasaki, K.
FUNCTIONAL EXPRESSION OF NMDA RECEPTOR CHANNELS IN DIFFERENTIAT-ING NEURAL PRECURSOR CELLS Yamada, K., Hisatsune, T., Uchino, S., Nakamura, T., Kudo, Y. and Kaminogawa, S.
LINE
INDUCES CELL SENESCENCE IN ADENOCARCINOMA CELL
Katakura, Y., Nakata, E., Miura, T. and Shirahata, S.
Poster Session
Cell Culture Engineering
EVALUATION OF A FIXED-BED TYPE BIOREACTOR SYSTEM USING RECOMBI-NANT CHO CELLS PRODUCING HUMAN TRANSFERRIN Nemoto, A., Hirota-Iwai, Y., Miyazaki, Y., Nakamichi, N., Ito, M., Tokiwa, T., Kodama, M. and Matsumura, T.
FORMATION OF CYLINDRICAL MULTICELLULAR AGGREGATE (CYLINDROID) OF RAT HEPATOCYTES ON PRESSED SHEET OF POLYURETHANE FOAM Mizumoto, H., Kaneko, M., Nakazawa, K., Ijima, H., Matsushita, T. and Funatsu, K.
PRODUCTION OF A NOVEL FUSION PROTEIN FOR USE I N SERUM-FREE MEDIA Simula, A. P., Barone, C., Priebe, I. K., Francis, G., Ballard, F. J., Wheldrake, J. and Goddard, C.
EFFECT OF THE MACROMOLECULAR METABOLISM OF MUR1NE HYBRIDOMA CELLS ON ANTIBODY PRODUCTIVITY IN BATCH AND FED-BATCH CULTURE Jang, J. D. and Barford, J. P.
EFFECT OF GLYCINE BETAINE AS OSMOPROTECTANT ON THE PRODUCTION OF ERYTHROPOIETIN BY CHO CELLS IN HYPEROSMOTIC SERUM FREE MEDIA CULTURE Ahn, Y.-H., Han, K., Yoon, S. K. and Song, J.-Y.
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199
205
211
217
223
229
235
241
247
X
Expression of Recombinant Animal Genes in Cultured Animal Cells
ESTA B LISH M EN T OF R E C O M B IN A N T CHO CELL L IN E S PRODUCING WILD-TYPE AND MUTANT HUMAN Nakamichi, N., Shimizu, M., Ito, M., Ikai, A. and Matsumura, T.
251
EVALUATION OF STABILITY IN THE DHFR GENE AMPLIFICATION SYSTEM USING FLUORESCENCESITU IN  HYBRIDIZATION N a k a n is h i, F., Yoshikawa, T., I t a m i , S., Omasa, T., Katakura, Y., K ishim oto, M. and 259 Suga, K.
EXPRESSION A N D CHARACTERIZATION OF H U M A N CALPAIN A N D CALPASTATIN U S IN G B A C U LO V IR U S SYSTEM Hitomi, K. and Maki, M.
Cell Characterization and Validation
EVALUATION OF SPIM INSECT CELLS USING A NOVEL BACULOVIRUS EXPRES-SION VECTOR SYSTEM EMPLOYING THECUNEA HYPHANTRIA  NPV Takenaka, Y., K obayashi, J., M atsuda, Y., Gong, C., Nagaya, M ., M i y a j i m a , S. and Yoshimura, T.
Transplantation and Artificial Organs
DEVELOPMENT OF A HYBRID ARTIFICIAL LIVER SUPPORT SYSTEM WITH P O R C IN E HEPATOCYTE SPHEROIDS FOR PRECLINICAL USE Kaneko, M ., Ito, T., N akazaw a, K., Ijim a, H., M atsu sh ita, T., G ion, T., Shimada, M., Shirabe, K., Hasegawa, H., Takenaka, K., S ugim achi, K. and F unatsu, K.
IN VITRO SELF-ORGANIZATION OF LIVER CELLS USING ARTIFICIAL MATRIX Yamada, K ., K am ihira, M., Hamamoto, R. and Iijima S.
265
271
277
283
THYROID TRANSPLANTATION: POSSIBILITY OF APPLICATION FOR THE TREAT-MENT OF PERSISTENT HYPOTHYROIDISM AND STUDY OF MECHANISMS OF INTERACTION BETWEEN GRAFT AND HYPOTHALAMIC-PITUITARY AXIS OF RECIPIENT Pasteur, I. P., Tronko, N. D., Drozdovich, I. I., Turchin, I. S. and Balla, I. A. 289
FIXED-BED REACTORS AS A TOOL FOR ARTIFICIAL ORGANS Pörtner, R., Rössing, S., Stange, J. and Fassnacht, D.
Transgenic Technology
TRANSCRIPTIONAL ACTIVITIES OF VIRAL AND CELLULAR PROMOTERS IN VIVON THE OVIDUCT OF L  I CHICKENSI V I N G Park, H.-M., Okumura, J. and Muramatsu, T.
295
299
LIVE DETECTION OF THE FIREFLY LUCIFERASE GENE EXPRESSION IN BOVINE PREIMPLANTATION EMBRYOS N a k a m u ra , A., O kum ura, J. and M uram atsu, T.
LOCALIZED IN VIVOTRANSFER IN SPERMATOGENIC CELLS OF  GENE THE CRYPTORCHID MOUSE TESTIS Muramatsu, T., Ryoki, S., Ohmori, Y. and Okumura, J.
Antibody Technology
PREPARATION OF A BISPECIFIC ANTIBODY TO OVOMUCOID AND HORSERADISH PEROXIDASE Shinmoto, H., M iyakoshi, S., Kobori, M., Yonekura, M., Shinohara, K. and Tsushida, T.
VITAMIN A ACETATE FOR EFFICIENT PRODUCTION OF MONOCLONAL ANTI-BODY BY H U M A N - H U M A N HYBRIDOM AS Inoue, Y, Fujisawa, M., Kawamoto, S., Shoji, M., Hashizume, S., K atak u ra, Y., Fujii, M. and Shirahata, S.
Cytokines and Signal Transduction
INDUCTION OF APOPTOSIS BY OSTEOPONTIN IN MDCK CELLS Fujimagari, H., K am ihira, M. and Iijima, S.
A N A LY SIS OF GLYCOSPHINGOLIPIDS ON DIFFERENTIATION-INDUCTION OF PC12 PHEOCHROMOCYTOMA CELLS BY MANNOSYLERYTHRITOL LIPID Shibahara, M., Isoda, H., M urata, T., Yokoyama, K. and Nakahara, T.
MANNOSYLERYTHRITOL LIPID INDUCES ANTI-PROLIFERATION AND DIFFER-ENTIATION OF MOUSE M E L A N O M A B16 CELLS Zhao, X. X., Isoda, H., M urata, T., Yokoyama, K. and N akahara, T.
S IG N A L TRANSDUCTION OF DIFFERENTIATION-INDUCTION BY M ANNOSYLERYTHRITOL LIPID ON PC12 PHEOCHROMOCYTOMA CELLS Wakamatsu, Y., Isoda, H., M urata, T., Yokoyama, K. and N akahara, T.
x
i
303
307
3 1 1
317
323
329
335
341
ALTERED EXPRESSION OF THE CIP/K IP FAMILY CDK I N H I B I T O R S I N TUMOR PHENOTYPE-SUPPRESSED H U M A N L U N G CANCER CELLS Kawamoto, S., Katakura, Y., Ono, K. and Shirahata, S. 347
Cell Culture for Assessment of Physiologically Functional Substances
S C R E E N IN G FOR BIOACTIVE COMPOUNDS THAT IN D U C E THE D IFFE R E N T IA -TION OF BONE M A R R O W - D E R I V E D PREADIPOCYTIC CELL L IN E , ST2, INTO THE CELLS OF OSTEOBLASTICPHENOTYPE S h i m i z u , T., Woo, J.-T. and Nagai, K.
353
x i i
STRUCTURE A N D FUNCTION OF SUCCINOYL TREHALOSE LIPID ON DIFFERENTIATION-INDUCTION OF HUMAN PROMYELOCYTIC LEUKEMIA CELL L IN E HL-60 Sudo, T., Isoda, H ., Kobori, M ., M urata, T., Yokoyama, K. and Nakahara, T.
THE ESTABLISHMENT OF AN ASSAY SYSTEM FOR THE COMPOUNDS AFFECT-ING ACTIN RING FORMATION OF MURI NE OSTEOCLAST-LIKE CELLS K asai, S., Takami, M ., Woo, J.-T. and Nagai, K.
PROTECTION OF H U M A N M ELA N O M A CELLS FROM UV DAMAGE BY A FERM ENTED M I L K , KEFIR Nagira, T., Narisawa, J., Kusum oto, K., Teruya, K., Katakura, Y., Barnes, D. W., Tokumaru, S. and Shirahata, S.
IDENTIFICATION OF SPECIFIC GENES INVOLVED IN CELLULAR SENESCENCE BY USING H U M A N LUNG ADENOCARCINOMA DERIVED CELLS U ehara, N ., K atak u ra, Y., Nishim oto, S., Teruya, K. and Shirahata, S.
L A M I N I N CHAINS EXPRESSED IN HUMAN KERATINOCYTES, MOUSE 3T3-L1 ADIPOCYTES AND MOUSE EMBRYONAL CARCINOMA F9 N i i m i , T., Kumagai, C., A zim i, M. and Kitagawa, Y.
Author Index
Subject Index
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381
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389
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