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*Haematologica ELT10 Medline prev htm> index next *The CD4+ CD56+ CD116 CD123+ CD45RA+ CD45RO profile is specific to DC2 malignancies* Trimoreau Franck Donnard Magali Turlure Pascal Gachard Nathalie Bordessoule Dominique Feuillard Jean Correspondence: Jean Feuillard Laboratoire d Hématologie CHU Dupuytren av Martin Luther King Limoges France Phone Fax number CD4+ CD56+ malignancies also called blastic NK lymphoma leukemia are a recently described entity^1 and blast cells are considered as the leukemic counterpart of type dendritic cells DC2 Differential diagnosis may sometimes be difficult because it is based mainly on the absence of B T or myeloid lineage markers lin in addition to CD4 and CD56 expression This stresses the need for other specific criteria to recognize these tumors independently of the lin profile Like on normal DC2 co expression of the IL receptor CD123 and CD45RA in the absence of GM CSF receptor CD116 and CD45RO was systematically observed in these tumors Moreover CD36 was expressed in most cases CD123 is widely expressed in AML It has been identified as a marker for AML stem cells CD34+CD38 leukemia cells CD116 has been preferentially associated with M4 M5 subtype of AML but is not specific^7 Neither CD45RA nor CD45RO is lineage specific CD36 is expressed by monocytic erythroblast and megakaryoblast cells This raises the question of the specificity of a DC2 immunophenotypic profile rather than of each individual marker We therefore evaluated the expression of CD4 CD56 CD123 CD116 CD45RA CD45RO and CD36 in acute leukemia and myelodysplastic syndromes MDS in order to evaluate the specificity of a DC2 malignancies profile that we defined as CD4+ CD56+ CD116 CD123+ CD45RA+ CD45RO Ninety six patients were studied according to FAB and EGIL recommendations with single lineage acute myeloid leukemia AML M0: M1: M2: M3: M4: M5: M6: M7: unclassified with ...

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variational proof of global stability for bistable travelling waves
Thierry Gallay Institut Fourier
UniversitedeGrenobleI 38402Saint-Martin-dHeres France
Emmanuel Risler Institut Camille Jordan INSA de Lyon 69621 Villeurbanne France
June 19, 2007
We give a variational proof of global stability for bistable travelling waves of scalar reaction-di usion equations on the real line. In particular, we recover some of the classical results by P. Fife and J.B. McLeod (1977) without any use of the maximum principle. The method that is illustrated here in the simplest possi-ble setting has been successfully applied to more general parabolic or hyperbolic gradient-like systems.
The purpose of this work is to revisit the stability theory for travelling waves of reaction-di usion systems on the real line. We are mainly interested inglobalstability results which assert that, for a wide class of initial data with a speci ed behavior at in nit y, the solutions approach for large times a travelling wave with nonzero velocity. In the case of scalar reaction-di usion equations, such properties have been established by Kolmogorov, Petrovski & Piskunov [11], by Kanel [9, 10], and by Fife & McLeod [4, 5] under various assumptions on the nonlinearity. The proofs of all these results use a priori estimates and comparison theorems based on the parabolic maximum principle. Therefore they cannot be extended to general reaction-di usion systems nor to scalar equations of a di eren t type, such as damped hyperbolic equations or higher-order parabolic equations, for which no maximum principle is available. However, these methods have been successfully applied tomonotonereaction-di usionsystems[15,18],aswellastoscalarequationsonin nite cylinders [14, 16]. Recently,adi erentapproachtotheglobalstabilityofbistabletravellingwaveshas been developped by the second author [13]. The new method is of variational nature and is therefore restricted to systems which admit a gradient structure, but it does not make any use of the maximum principle and is therefore potentially applicable to a wide class
of problems. The goal of this paper is to explain how this method works in the simplest possible case, namely the scalar parabolic equation ut=uxx F0(u),(1) whereu=u(x, t)R,xR, andtshall thus recover the main result of0. We Fife & McLeod [4] under slightly di eren t assumptions on the nonlinearityF, with a completely di eren t proof. The present article can also serve as an introduction to the more elaborate work [13], where the method is developped in its full generality and applied totheimportantcaseofgradientreaction-di usionsystemsoftheformut=uxx rV(u), withuRnandV:RnR. A further application of our techniques is given in [7], where the global stability of travelling waves is established for the damped hyperbolic equation utt+ut=uxx F0(u), with >0. We thus consider the scalar parabolic equation (1), which models the propagation of fronts in chemical reactions [2], in combustion theory [9, 10], and in population dynamics [1, 6]. We suppose that the “potential”F:RRis a smooth, coercive function with a unique global minimum and at least one additional local minimum. More precisely, we assume thatF∈ C2(R) satis es u)>0.(2) l|iu|minfF0(u In particular,F(u)+as|u| → ∞ also assume that. WeFreaches its global minimum atu= 1: F(1) = A <0, F0(1) = 0, F00(1)>0,(3)
and has in addition a local minimum atu= 0: F(0) =F0(0) = 0, F00(0) = >0.
Finally, we suppose that all the other critical values ofFare positive, namely nuR0(u) = 0, F(u)0o={0 ; 1}. F A typical potential satisfying the above requirements is represented in Fig. 1.
Under assumptions (3)-(5), it is well-known that Eq.(1) has a family of travelling waves of the formu(x, t) =h(x ct) connecting the stable equilibriau= 1 andu= 0. More precisely, there exists a unique speedc>0 such that the boundary value problem hh0(0 (y)+)c=h10(,y) h(F+0(h()y))0=0=, yR,(6) ,
has a solutionh:R(0,teehrp ohwcichsa1),inlehitself is unique up to a translation. Moreoverh∈ C3(R),h0(y)<0 for allyR, andh(y) converges exponentially to its limits asy→ ∞. This family of travelling waves plays a major role in the dynamics of Eq.(1), as is shown by the following global convergence result: