The Synthetic Organic Chemist
208 Pages
English

The Synthetic Organic Chemist's Companion

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Description

The Organic Chemists' Companion provides a practical, hands-on resource for students and practitioners of organic synthesis. It presents the fundamentals and guides the reader through the entire process of organic synthesis. It includes basic instructions on everything from on handling reagents, gases, and solvents to conducting and working up/purifying reactions as well as applying analytical techniques to identify the reaction product.
  • Packed with data and practical tips and organized for quick reference
  • Includes guidelines for literature searches to help readers find additional information
  • Features colour photos, drawings, charts, graphs, and tables to complement the information
  • Includes real-life examples showing how to apply the information.

Subjects

Informations

Published by
Published 23 May 2007
Reads 0
EAN13 9780470141038
License: All rights reserved
Language English

Legal information: rental price per page €. This information is given for information only in accordance with current legislation.

Preface.
Acknowledgments.
1. Searching the Literature.
1.1. Commercial availability.
1.2. Literature preparations.
2. Reagents.
2.1. Short path distillation.
2.2. Ampules.
2.3. Reagent solutions.
2.4. Titration.
2.5. Reagent storage.
2.6. Subtle reagent variations.
2.7. Dangerous reagents.
2.8. Reagent properties.
3. Gases.
3.1. Lecture bottles.
3.2. Tanks or cylinders.
3.3. Gas safety.
4. Reactions on a Small Scale - 1-25 mmol.
4.1. Reaction flasks.
4.2. Stirring.
4.3. Glass joints.
4.4. Inert atmosphere.
4.5. Apparatus for addition.
4.6. Condensers.
4.7. Other equipment and considerations.
5. Temperature Control.
5.1. Heating.
5.2. Cooling.
6. Solvents.
6.1. Selection.
6.2. Purity.
6.3. Degassing.
6.4. Ammonia.
7. The Research Notebook.
8. Conducting the Reaction Itself.
8.1. Reagents supplied as dispersions.
8.2. Azeotropic drying.
8.3. Stoichiometry.
8.4. Syringe and inert atmosphere techniques.
8.5. General procedure for transfer of materials by syringe.
8.6. Addition.
8.7. Special techniques.
8.7.1.Water removal.
8.7.2.Reactions above atmospheric pressure.
8.7.3.Reagent gases.
8.7.4.Ultrasonication.
8.8 Quenching .
8.9. Specialized reagents.
8.9.1. Diazomethane.
8.9.2. Lithium aluminum hydride.
8.9.3.Hydrogen peroxide.
8.10. Reaction time vs. purification time.
9. Following the Reaction.
9.1. Thin layer chromatography (TLC).
9.1.1. Cutting glass TLC plates.
9.1.2. Spotting TLC plates.
9.1.3. Eluting TLC plates.
9.1.4. Visualizing TLC plates.
9.2. Gas chromatography (GC).
9.3. High pressure liquid chromatography (HPLC).
9.4. NMR spectroscopy.
10. Working Up Reactions.
10.1. Solvent extracation.
10.2. Drying organic solutions.
10.3. Specialized work-ups.
10.3.1. Reactions producing triphenylphosphine oxide.
10.3.2. Reactions involving boron compounds.
10.3.3. Reactions involving copper salts.
10.3.4. Reactions involving aluminum reagents.
10.3.5. Reactions involving tin reagents.
11. Evaporation.
12. Vacuum Systems.
12.1. Vacuum sources.
12.2. Vacuum manifolds.
12.3. Vacuum gauges.
13. Purification of Products.
13.1. Distillation.
13.2. Silica gel chromatography.
13.3. Flash column chromatography.
13.4. Gradients.
13.5. Special absorbents.
13.5.1. Triethylamine-treated silica gel.
13.5.2. Oxalic acid-coated silica gel.
13.5.3. Silver nitrate-impregnated silica gel.
13.5.4. Other sorbents.
13.6. Preparative gas chromatography.
14. Methods for Structure Elucidation.
14.1. Nuclear magnetic resonance spectroscopy.
14.2. Infrared spectroscopy (IR).