Application of Apoptosis to Cancer Treatment

Application of Apoptosis to Cancer Treatment

English

Description

Novel drugs are being developed which interact with the programmed cell death (apoptotic) machinery in cancer cells, thereby causing these cells to commit suicide and to be removed from the body. Research is also directed to investigate why the cancer cells sometimes lose the ability to undergo apoptosis after a certain period of time and methods are being developed to reactivate this cell death process. This book is intended for workers in the field and clinicians as a useful guide of the state of affairs in this exciting field which may offer more effective possibilities for treatment of cancer patients.

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Published 01 January 2005
Reads 6
EAN13 1402033028
License: All rights reserved
Language English

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TABLE OF CONTENTS
Chapter 1 Disfunction of the Apoptotic Pathwayin Cancer Cells..............................1 Lily Yang
Chapter 2 Calcium Signaling and Apoptosis Resistance of Cancer Cells ................29 Natalia Prevarskaya, Roman Skryma and Yaroslav Shuba
Chapter 3 CellClearance andCancer .........................................................................51 Bengt Fadeel
Chapter 4 Specific, ProPoptotic CellSignaling: Design of Novel, Recombinant Targeted Antitumor Agents Operating Exclusively Through Modulation of Cellular Apoptotic Events: Novel, Targeted ProApoptoticTherapeutic Agents ..................85 YuyingLiu, Lawrence H. Cheungand Michael G. Rosenblum
Chapter 5 Targeting Oncogenes which Regulate Apoptosis....................................117 Andrew C. Phillips
Chapter 6 Targeting Cyclins to Cause Cancer CellApoptosis................................145 Suparna Mazumder, Dragos Plesca and Alexandru Almasan
Chapter 7 Apoptosis Induction by TumorTargeted Toxins ...................................179 AndrewThorburn
vi
Chapter 8 Targeting CellDeath Pathways in Multiple Myeloma: TherapeuticImplications ..........................................................................189 DharminderChauhan and Kenneth Anderson
Chapter 9 Cephalostatin 1Induced Apoptosis in Tumor Cells Selective Induction of Smac/DIABLO Release .......................................209 Verena M. Dirsch and Angelika M. Vollmar
Chapter10 Hamlet; a Novel Tool to Identify Apoptotic Pathways in TumorCells................................................................................................223 Caroline Düringer, Oskar Hallgren, Lotta Gustafsson, Jenny Petterson, Ann-Kristin Mossberg, Taras Manilov and Catharina Svanborg
Chapter 11 Cancer Immunotherapy: On the Trail of a Cure? .................................247 Thomas S. Griffith, TroyKemp1, Aaron T. Ludwi J. g, Jill M. Moore, and Rebecca L. VanOosten
Chapter 12 Histone Deacetylase Inhibitors as a Treatment of Trail ResistantCancers ......................................................................................271 Jiri Neuzil,Ladislav Andera and Brian Gabrielli
Chapter 13 Basis ofCellKillFollowingClinicalRadiotherapy................................293 Oliver Faulhaber and RobertGBristow
Chapter 14 I..........................................................321maging of Apoptotic Cells in Vivo Juhana Hakumäki
Chapter15 ApoptosisInducing Anticancer Drugs inClinical Trials.......................341 Wei Hu and John J. Kavanagh
Index ...........................................................................................................365