Braunwald's Heart Disease E-Book


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Ideal for cardiologists who need to keep abreast of rapidly changing scientific foundations, clinical research results, and evidence-based medicine, Braunwald’s Heart Disease is your indispensable source for definitive, state-of-the-art answers on every aspect of contemporary cardiology, helping you apply the most recent knowledge in personalized medicine, imaging techniques, pharmacology, interventional cardiology, electrophysiology, and much more!

  • Practice with confidence and overcome your toughest challenges with advice from the top minds in cardiology today, who synthesize the entire state of current knowledge and summarize all of the most recent ACC/AHA practice guidelines.
  • Locate the answers you need fast thanks to a user-friendly, full-color design with more than 1,200 color illustrations.
    • Learn from leading international experts, including 53 new authors. Explore brand-new chapters, such as Principles of Cardiovascular Genetics and Biomarkers, Proteomics, Metabolomics, and Personalized Medicine.
    • Access new and updated guidelines covering Diseases of the Aorta, Peripheral Artery Diseases, Diabetes and the Cardiovascular System, Heart Failure, and Valvular Heart Disease.
    • Stay abreast of the latest diagnostic and imaging techniques and modalities, such as three-dimensional echocardiography, speckle tracking, tissue Doppler, computed tomography, and cardiac magnetic resonance imaging.
    • Consult this title on your favorite e-reader, conduct rapid searches, and adjust font sizes for optimal readability.



    Published by
    Published 30 July 2014
    Reads 0
    EAN13 9780323290647
    Language English
    Document size 29 MB

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    Braunwald's Heart Disease
    A Textbook Of Cardiovascular Medicine
    Edited by
    Douglas L. Mann, MD
    Lewin Chair and Professor of Medicine, Cell Biology, and Physiology Chief, Division of Cardiology Washington University School of Medicine in St. Louis Cardiologist-in-Chief Barnes-Jewish Hospital St. Louis, Missouri
    Douglas P. Zipes, MD
    Distinguished Professor Professor Emeritus of Medicine, Pharmacology, and Toxicology Director Emeritus, Division of Cardiology and the Krannert Institute of Cardiology Indiana University School of Medicine Indianapolis, Indiana
    Peter Libby, MD
    Mallinckrodt Professor of Medicine Harvard Medical School Chief, Cardiovascular Medicine Division Brigham and Women's Hospital Boston, Massachusetts
    Robert O. Bonow, MD, MS
    Max and Lilly Goldberg Distinguished Professor of Cardiology Vice Chairman, Department of Medicine Director, Center for Cardiac Innovation Northwestern University Feinberg School of Medicine Chicago, Illinois Founding Editor and Online Editor
    Eugene Braunwald, MD, MD(Hon), ScD(Hon), FRCP
    Distinguished Hersey Professor of Medicine Harvard Medical School Founding Chairman, TIMI Study Group Brigham and Women's Hospital Boston, Massachusetts
    Table of Contents
    Cover image
    Title page
    Preface to the Tenth Edition
    Preface—Adapted from the First Edition
    Video Contents
    Look for these other titles in the Braunwald's Heart Disease Family Part I Fundamentals of Cardiovascular Disease
    1 Global Burden of Cardiovascular Disease
    Shifting Burden of Cardiovascular Disease
    Epidemiologic Transition in Predominant Causes of Death
    Current Variations in the Global Burden of Cardiovascular Disease
    Risk Factors
    Economic Burden
    Cost-Effective Solutions
    Summary and Conclusions
    2 Heart Disease in Varied Populations
    Changing Demographics of the U.S. Population
    Distribution of Known Risk Factors for Heart Disease
    Coronary Heart Disease
    Heart Failure
    3 Ethics in Cardiovascular Medicine
    Informed Consent and Shared Decision Making
    End-of-Life Care
    Ethics of Clinical Research
    Resource Allocation
    Conflict of Interest
    4 Clinical Decision Making in Cardiology
    Diagnostic Decision Making: General Considerations
    Diagnostic Testing
    Therapeutic Decision Making
    Accuracy of Study Results
    Cognitive Errors
    Shared Decision Making
    Systems of Care
    Classic Readings
    5 Measurement and Improvement of Quality of Care: Relevance to Cardiovascular
    Clinical Practice
    Defining Quality of Care
    Measuring Health Care Quality and Uses of Quality Measurements
    6 Critical Evaluation of Clinical Trials
    Constructing the Research Question
    Clinical Trial Design
    Key Issues
    Measures and Detection of Treatment Effect
    Future Perspectives
    Part II Genetics and Personalized Medicine
    7 Personalized and Precision Cardiovascular Medicine
    Assessment of Disease Risk: Family Health History and Health Risk Assessments
    A Genomic Toolbox for Personalized and Precision Medicine
    Gene Expression
    Personalized and Precision Cardiovascular Medicine: Clinical Potential
    Barriers and Solutions to the Integration of Genomics Into Cardiovascular Medicine
    Future Perspective: Toward Personalized and Precision Cardiovascular Medicine
    8 Principles of Cardiovascular Genetics
    Inherited Basis for the Variation in Risk for Cardiovascular Disease
    A Brief Primer on Molecular Biology
    Modes of Inheritance
    Approaches to Discovering the Inherited Basis for Cardiovascular Disease
    Illustrative Examples
    Clinical Application of Genetic Findings
    Future Directions
    9 Drug Therapeutics and Personalized Medicine
    Importance of Correct Drug Use
    The Key Decision in Drug Therapy: Risk Versus Benefit
    Mechanisms Underlying Variability in Drug Action
    Molecular and Genetic Basis for Variable Drug Response
    Optimizing Drug Doses
    Future Challenges
    10 Biomarkers, Proteomics, Metabolomics, and Personalized Medicine
    What is a Biomarker?
    Introduction to Proteomics and Metabolomics
    Overview of the Discovery Process
    Clinical Measures of Biomarker Performance
    Part III Evaluation of the Patient
    11 The History and Physical Examination: An Evidence-Based Approach
    The History
    The General Physical Examination
    The Cardiovascular Examination
    Integrated, Evidence-Based Approach to Specific Cardiac Disorders
    Future Directions
    12 Electrocardiography
    The Normal Electrocardiogram
    The Abnormal Electrocardiogram
    Clinical Issues in Electrocardiographic Interpretation
    Future Perspectives
    13 Exercise Testing
    Physiology of Exercise Testing
    Technical Aspects of Exercise Testing
    Exercise Testing in Patients with Coronary Artery Disease
    Exercise Testing in Patients with Nonatherosclerotic Heart Disease
    Additional Uses of Exercise Testing
    Classic Reading List
    14 Echocardiography
    Principles of Ultrasound and Instrumentation
    Principles of Doppler Imaging
    The Standard Adult Transthoracic Echocardiographic Examination
    Transesophageal Echocardiography
    Three-Dimensional Echocardiography
    Echocardiography in the Context of Cardiac Imaging
    Myocardial Infarction
    Stress Echocardiography
    Valvular Heart Disease (see Chapter 63)
    Pericardial Disease (see Chapter 71)
    Diseases of the Aorta (see Chapter 57)
    Infective Endocarditis (see Chapter 64)
    Systemic Diseases and Echocardiography
    Pulmonary Hypertension (see Chapter 74)
    Cardiac Masses
    Congenital Heart Disease in Adults (see Chapter 62)
    Cardiac Procedures and Future Directions
    15 The Chest Radiograph in Cardiovascular Disease
    Technical Considerations
    The Chest Radiograph in Heart Disease
    16 Nuclear Cardiology
    Technical Aspects of Image Acquisition, Display, and Interpretation
    Myocardial Blood Flow, Myocardial Metabolism, and Ventricular Function
    Disease Detection, Risk Stratification, and Clinical Decision Making
    Molecular Imaging of the Cardiovascular System
    17 Cardiovascular Magnetic Resonance Imaging
    Basic Principles of Magnetic Resonance Imaging
    Patient Safety in Cardiac Magnetic Resonance
    Cardiac Magnetic Resonance Assessment of Specific Disorders and Conditions
    Novel Cardiac Magnetic Resonance Imaging Techniques
    Future Perspectives
    18 Cardiac Computed Tomography
    Patient Preparation and Scanning Sequence
    Cardiac Computed Tomography Anatomy
    Clinical Indications
    Incidental Scan Findings
    Training and Certification
    19 Cardiac Catheterization
    Indications for Diagnostic Cardiac Catheterization
    Technical Aspects of Cardiac Catheterization
    Hemodynamic Data
    Adjunctive Diagnostic Techniques
    Complications Associated with Cardiac Catheterization
    Future Perspectives
    20 Coronary Arteriography and Intracoronary Imaging
    Overview and Background
    Indications and Contraindications for Coronary Arteriography
    Technique of Coronary Arteriography
    Intracoronary Imaging
    Future Perspectives
    Part IV Heart Failure