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Clinical Neuroscience E-Book


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This book provides a clear and readable introduction to the central concepts of clinical neuroscience. The first part of the book deals with fundamental areas of neuroscience required for a sound understanding of brain disease. This is followed by an account of the neurobiology of the most common and important brain diseases of the western world (stroke, epilepsy, Alzheimer's disease, Parkinson's disease and multiple sclerosis). The book is in the same general style as the successful Crossman: Neuronatomy with extensive colour illustrations.

Short, affordable and readable introductory level text in the smae style as Crossman: Neuroanatomy.
Assumes little previous neuroscience knowledge.
Explains fundamental concepts without overwhelming detail
Focuses on clinically relevant material.
Includes the most common and important neurological disorders.



Published by
Published 17 April 2014
Reads 2
EAN13 9781455742127
Language English
Document size 15 MB

Legal information: rental price per page 0.0133€. This information is given for information only in accordance with current legislation.

Clinical Neuroscience
An Illustratep Colour Text
Paul Johns, BSc BM MSc FRCPath
Consultant Neuropathologist and Senior Lecturer in Neuroanatomy, St George's Healthcare NHS Trust and St George's University of London, London, UK
Table of Contents
Cover image
Title bage
Chabter 1: Overview of the nervous system
Parts of the nervous system
Cells of the nervous system
Basic cereral tobograbhy
The sbinal cord
Protective coverings of the CNS
Chabter 2: Develobment of the rain
Neural tue formation
Divisions of the rain
Ventricular system
Chabter 3: Functional neuroanatomy
Cereral cortex
Hibbocambus and amygdala
Basal ganglia
Thalamus and hybothalamus
Brain stem and cereellum
Chabter 4: Sensory and motor bathways
Sbinal segments
Somatic sensory bathways
Somatic motor bathways
Lower motor neurons
Reflexes and muscle tone
Chabter 5: Neurons and glial cells
Nerve cells
Oligodendrocytes and Schwann cells
Other glial cells
Glial tumours
Chabter 6: Electrical signalling in neurons
The neuron at rest
The action botential
Axonal conduction
Chabter 7: Synabtic transmission
General brincibles
Postsynabtic recebtors
Synabtic integration
Chabter 8: Cellular mechanisms of neurological disease
Neuronal injury and death
Cell death mechanisms
Inflammation and gliosis
Prion diseases
Chabter 9: Head injury
Clinical asbects
Pathology of head injury
Brain swelling and intracranial bressure
Minor head injury
Chabter 10: Stroke
Tybes of stroke
Blood subbly to the rain
Stroke management
Pathobhysiology of stroke
Chabter 11: Ebilebsy
Tybes of seizure
General asbects
Diagnosis and management
Neurobathology of ebilebsy
Partial seizure mechanisms
Mechanism of asence seizures
Sudden death in ebilebsy
Psychological asbects
Chabter 12: Dementia
General asbects
Alzheimer's disease
Dementia with Lewy odies
Vascular dementia
Frontotemboral dementia
Chabter 13: Parkinson's disease
Clinical features
Pathology of Parkinson's disease
Familial Parkinson's disease
Treatment of Parkinson's disease
Aetiology and bathogenesis
Chabter 14: Multible sclerosis
Clinical features of MS
Diagnosis and management
Pathological features
Neurodegeneration in MS
Anatomical language
© 2014 Elsevier Ltd. All rights reserved. No part of this publication may be reproduced or transmitted in any form or by any means, electronic or mechanical, including photocopying, recording, or any information storage and retrieval system, without permission in writing from the publisher. Details on how to seek permission, further information about the Publisher's permissions policies and our arrangements with organizations such as the Copyright Clearance Center and the Copyright Licensing Agency, can be found at our website:www.elsevier.com/permissions. This book and the individual contributions contained in it are protected under copyright by the Publisher (other than as may be noted herein). ISBN 978-0-443-10321-6 ebook ISBN 978-1-4557-4212-7
British Library Cataloguing in Publication Data A catalogue record for this book is available from the British Library
Library of Congress Cataloging in Publication Data A catalog record for this book is available from the Library of Congress
Knowledge and best practice in this field are constantly changing. As new research and experience broaden our understanding, changes in research methods, professional practices, or medical treatment may become necessary.
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Printed in China
For Iris,
Born on the 5th of December, 2013
This new addition to theIllustrated Colour Text(ICT) series provides a short, readable introduction to basic and clinical neuroscience. It is intended to contain ‘all you need to know’ to get a good understanding of the nervous system and its most important disorders. There are two main aims: Explain the core principles of cellular and molecular neuroscience, emphasising aspects that are important for understanding common brain diseases Provide an integrated, up-to-date description of the most important neurological disorders (such as stroke, epilepsy and dementia) and their scientific basis. This text should be an ideal companion to the very popularNeuroanatomy ICT by Crossman and Neary and has been written in the same chapter-based format. Although the book is not divided into sections, the second half is more clinically-orientated than the first. The earlier chapters introduce a number of core neuroscience topics, including the development, anatomy and cellular constituents of the nervous system. Some fundamental (and potentially confusing) concepts are explained, including the electrical properties of neurons and the principles of synaptic transmission. Before moving on to discuss speci*c neurological conditions in detail, there is an introductory chapter on the cellular mechanisms of neurological disease, which provides an overview of basic pathological processes (such as in+ammation, gliosis, cell death and neurodegeneration). The second half of the book focuses on the most common and important neurological disorders, with separate chapters on head injury, stroke, epilepsy, dementia, Parkinson's disease and multiple sclerosis. These provide a comprehensive and integrated introduction to each main disease, together with a number of associated and related conditions. Each chapter begins with the key clinical features (e.g., symptoms, signs and main imaging *ndings) before describing how each disorder is diagnosed and treated. Sections on aetiology and pathogenesis draw on relevant aspects of anatomy, pathology, physiology and pharmacology. In addition, numerous ‘clinical boxes’ (with a blue stethoscope icon) are scattered throughout the text, highlighting a wide range of neurological diseases, investigations and treatments. Neuroscience is a challenging subject that is easier (and more interesting) to learn when it is understood rather than memorised; for this reason, emphasis has been