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Enzinger and Weiss's Soft Tissue Tumors E-Book


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Enzinger and Weiss's Soft Tissue Tumors is your essential medical reference on the diagnosis of tumors of the skeletal muscles, connective tissue, fat, and related structures. No other source matches Enzinger and Weiss’s scope and depth of coverage in this complex and challenging area of surgical pathology, and no other text contains as much practical information on differential diagnosis. Microscopic findings are correlated with the latest developments in molecular biology, cytogenetics, and immunohistochemistry, providing you with a comprehensive and integrated approach to the evaluation of soft tissue specimens.

  • Consult this title on your favorite e-reader, conduct rapid searches, and adjust font sizes for optimal readability.
  • Compare what you see under the microscope to nearly 2,000 superb images that capture the appearance of a complete range of pathological entities and help you relate their characteristics to their specific classifications.
  • Apply the latest knowledge on FNA biopsy, molecular biology, and cytogenetics.
  • Make rapid and effective decisions with the aid of extensive algorithms, and access information at a glance with abundant tables and graphs.
  • Take advantage of all of the essential clinical and prognostic data on soft tissue tumors that are necessary to formulate complete sign-out reports.
  • Navigate through the book quickly thanks to summary outlines at the beginning of each chapter, a color-coded page design, and a consistent approach to every entity.
  • Apply the latest advances in surgical pathology thanks to major updates on recently identified pathological entities such as soft tissue angiofibroma and CIC-related sarcomas; coverage of the newest molecular diagnostic techniques and immunohistochemical and molecular genetic features of soft tissue tumors; new chapters on GIST and soft tissue tumors showing melanocytic differentiation; and more.
  • Effortlessly find the information you need with a chapter organization based on the newest surgical pathology concepts and classifications of soft tissue tumors.



Published by
Published 11 October 2013
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EAN13 9781455737635
Language English
Document size 184 MB

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Enzinger and Weiss's Soft Tissue Tumors
John R. Goldblum, MD, FCAP, FASCP, FACG Chairman, Department of Anatomic Pathology, Cleveland Clinic Professor of Pathology, Cleveland Clinic Lerner Col lege of Medicine Cleveland, Ohio
Andrew L. Folpe, MD Professor of Laboratory Medicine and Pathology Director, Bone and Soft Tissue Pathology Fellowship College of Medicine Mayo Clinic Rochester, Minnesota
Sharon W. Weiss, MD Professor of Pathology and Laboratory Medicine Associate Dean for Faculty Affairs Emory University School of Medicine and Hospital Atlanta, Georgia
Table of Contents
Cover image
Title Page
Preface to the Sixth Edition
Preface to the First Edition
Chapter 1 General Considerations Incidence of Soft Tissue Tumors Pathogenesis of Soft Tissue Tumors
Classification of Soft Tissue Tumors
Grading and Staging Soft Tissue Sarcomas References
Chapter 2 Clinical Evaluation and Treatment of Soft Tissue Tumors Introduction Clinical Evaluation
Prognostic Factors
Treatment of Localized Primary Extremity Sarcomas
Treatment of Locally Advanced Disease
Management of Local Recurrence Key Points
Chapter 3 Radiologic Evaluation of Soft Tissue Tumors Introduction Imaging Modalities
Imaging Features of Common Benign Soft Tissue Tumors
Uncommon Benign Soft Tissue Tumors
Uncommon Malignant Soft Tissue Tumors
Common Tumor-Like Conditions
Uncommon Tumor-Like Conditions References
Chapter 4 Cytogenetic and Molecular Genetic Pathology of Soft Tissue Tumors Introduction General Concepts in Cancer Genetics
General Principles of Translocations
Diagnostic Methods
Major Pathogenetic Classes of Sarcomas
Sarcomas with Chimeric Transcription Factors
Sarcomas with Genetic Deregulation of Kinase Signaling
Sarcomas with Complex Karyotypes
Chromosome Changes in Benign Mesenchymal Tumors
Genetics of Familial Sarcomas and Their Sporadic Counterparts
Contributions of Pan-Genomic Studies to Sarcoma Diagnosis and Classification References
Chapter 5 Fine-Needle Aspiration Biopsy of Soft Tissue Tumors Introduction Advantages and Disadvantages of Fine-Needle Aspiration
Myxoid Sarcomas
Spindle Cell Sarcomas
Pleomorphic Sarcomas
Polygonal Cell Sarcomas
Round Cell Sarcomas
Miscellaneous Sarcomas
Accuracy of Fine-Needle Aspiration
Grading and Fine-Needle Aspiration Conclusions References
Chapter 6 Approach to the Diagnosis of Soft Tissue Tumors Clinical Information Biopsy Diagnosis
Frozen Section Diagnosis
Evaluation of Resection Specimens
Microscopic Examination
Molecular Tests
Diagnostic Nomenclature
Standardized Reporting of Soft Tissue Sarcomas References
Chapter 7 Immunohistochemistry for Analysis of Soft Tissue Tumors Intermediate Filaments Epithelial Membrane Antigen Markers of Muscle Differentiation Markers of Nerve Sheath Differentiation
Neuroectodermal Markers
Markers of Melanocytic Differentiation
Markers of Endothelial Differentiation
Markers of Gastrointestinal Stromal Tumors
Use of Immunohistochemistry as a Surrogate for the Presence of Tumor-Specific Molecular Alterations
Other Markers
Prognostic Markers
Application of Immunohistochemistry to Sarcoma Diagnosis: Clinical Scenarios
Conclusion References
Chapter 8 Benign Fibroblastic/Myofibroblastic Proliferations, Including Superficial Fibromatoses Benign Fibroblastic/Myofibroblastic Proliferations Nodular Fasciitis
Proliferative Fasciitis
Proliferative Myositis
Organ-Associated Pseudosarcomatous Myofibroblastic Proliferations
Ischemic Fasciitis (Atypical Decubital Fibroplasia)
Fibroma of Tendon Sheath
Pleomorphic Fibroma of the Skin
Nuchal-Type Fibroma
Gardner-Associated Fibroma
Nasopharyngeal Angiofibroma Keloid Desmoplastic Fibroblastoma (Collagenous Fibroma)
Intranodal Palisaded Myofibroblastoma
Mammary-Type Myofibroblastoma
Superficial Acral Fibromyxoma (Digital Fibromyxoma)
Angiofibroma of Soft Tissue
Superficial Fibromatoses
Palmar Fibromatosis
Plantar Fibromatosis
Penile Fibromatosis (Peyronie Disease)
Knuckle Pads References
Chapter 9 Fibrous Tumors of Infancy and Childhood Fibrous Hamartoma of Infancy Infantile Digital Fibromatosis
Myofibroma and Myofibromatosis
Juvenile Hyaline Fibromatosis/Infantile Systemic Hyalinosis
Gingival Fibromatosis
Fibromatosis Colli
Infantile Fibromatosis (Lipofibromatosis)
Calcifying Aponeurotic Fibroma
Congenital and Acquired Muscular Fibrosis
Cerebriform Fibrous Proliferation (Proteus Syndrome)
Calcifying Fibrous Pseudotumor References
Chapter 10 Borderline and Malignant Fibroblastic/Myofibroblastic Tumors Deep (Desmoid-Type) Fibromatoses Congenital/Infantile Fibrosarcoma
Inflammatory Myofibroblastic Tumor
Adult-Type Fibrosarcoma
Fibrosarcoma Variants References
Chapter 11 Benign Fibrohistiocytic and Histiocytic Tumors Fibrous Histiocytoma Variants of Benign Fibrous Histiocytoma
Atypical Fibrous Histiocytoma
Cellular Neurothekeoma
Solitary (Juvenile) Xanthogranuloma
Solitary Reticulohistiocytoma
Multicentric Reticulohistiocytosis Xanthoma
Miscellaneous Histiocytic Reactions Resembling a Neoplasm References
Chapter 12 Fibrohistiocytic Tumors of Intermediate Malignancy Dermatofibrosarcoma Protuberans Sarcoma Arising in Dermatofibrosarcoma Protuberans (Fibrosarcomatous Variant of Dermatofibrosarcoma Protuberans) Bednar Tumor (Pigmented Dermatofibrosarcoma Protuberans, Storiform Neurofibroma)
Giant Cell Fibroblastoma
Angiomatoid Fibrous Histiocytoma
Plexiform Fibrohistiocytic Tumor Soft Tissue Giant Cell Tumor of Low Malignant Potential References
Chapter 13 Undifferentiated Pleomorphic Sarcoma Pleomorphic Sarcoma with a Specific Line of Differentiation Atypical Fibroxanthoma (Undifferentiated Pleomorphic Sarcoma of the Skin)
Undifferentiated Pleomorphic Sarcoma References
Chapter 14 Benign Lipomatous Tumors White Fat Brown Fat
Molecular Biology of Benign Lipomatous Tumors
Immunohistochemistry of Benign Lipomatous Tumors
Classification of Benign Lipomatous Tumors Lipoma Multiple Lipomas Angiolipoma Myolipoma
Chondroid Lipoma
Spindle Cell/Pleomorphic Lipoma
Benign Lipoblastoma and Lipoblastomatosis
Angiomyolipoma Myelolipoma Intramuscular and Intermuscular Lipomas
Lipomas of Tendon Sheaths and Joints
Lumbosacral Lipoma
Neural Fibrolipoma (Lipofibromatous Hamartoma of Nerves)
Diffuse Lipomatosis
Symmetric Lipomatosis
Pelvic Lipomatosis
Steroid Lipomatosis
Nevus Lipomatosus Cutaneous Superficialis Hibernoma References
Chapter 15 Liposarcoma Criteria and Importance of Lipoblasts Atypical Lipomatous Neoplasm (ALN)/Well-Differentiated Liposarcoma (WDL)
Dedifferentiated Liposarcoma
Myxoid Liposarcoma
Pleomorphic Liposarcoma
Spindle Cell Liposarcoma
Liposarcoma of Mixed or Unclassifiable Type
Liposarcoma in Children
So-Called Multicentric Liposarcoma References
Chapter 16 Benign Tumors of Smooth Muscle Structure and Function of Smooth Muscle Cells Cutaneous Leiomyoma (Leiomyoma Cutis)
Angiomyoma (Vascular Leiomyoma)
Leiomyoma of Deep Soft Tissue
Leiomyomatosis Peritonealis Disseminata
Benign Genital Stromal Tumors
Miscellaneous Lesions Confused with Leiomyomas References
Chapter 17 Leiomyosarcoma Retroperitoneal/Abdominal Leiomyosarcomas Leiomyosarcomas of Somatic Soft Tissue
Cutaneous Leiomyosarcomas
Leiomyosarcomas of Vascular Origin
Miscellaneous Sarcomas of Vascular Origin
Epstein-Barr Virus-Associated Smooth Muscle Tumors References
Chapter 18 GIST and EGIST Epidemiology and Clinical Findings for Gastrointestinal Stromal Tumors Macroscopic Findings for Gastrointestinal Stromal Tumors
Microscopic Findings for Gastrointestinal Stromal Tumors
Immunohistochemical Findings for Gastrointestinal Stromal Tumors Ultrastructural Findings for Gastrointestinal Autonomic Nerve Tumors Genetics of Gastrointestinal Stromal Tumors
Succinate Dehydrogenase Deficient Gastrointestinal Stromal Tumors
Pediatric Gastrointestinal Stromal Tumors Gastrointestinal Stromal Tumor Syndromes Behavior of Gastrointestinal Stromal Tumors Treatment of Gastrointestinal Stromal Tumors Histologic Assessment of Treated Gastrointestinal Stromal Tumors References
Chapter 19 Rhabdomyoma Striated Muscle Tissue: Development and Structure