Killer Lymphocytes

Killer Lymphocytes

English

Description

We have known about the existence of killer lymphocytes since 1960, when they were discovered in connection with transplant rejection in vivo. Since then we have uncovered at least five subsets of lymphocytes that can kill other cells in vitro, establishing the study of cell-mediated cytotoxicity (CMC) as a major field of immunological inquiry. Berke and Clark summarize the extensive literature based on the study of CMC in vitro. Several important questions about killer cells have now been answered, for example, how they go about destroying other cells. Research ultimately revealed at least three lytic mechanisms available to killer lymphocytes. But do killer cells actually use these mechanisms in vivo? The possible involvement of CMC in transplant rejection, control of intracellular parasites, cancer, autoimmunity, and immune homeostatic regulation is analyzed in detail, yielding some surprising findings, and outlining important questions that remain unanswered.

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Published by
Published 01 January 2005
Reads 47
EAN13 1402032706
License: All rights reserved
Language English

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TABLE OF CONTENTS
Preface
Chapter 1 Basic Immunobiology: A Primer
Chapter 2 Cytotoxic T Lymphocytes:Generation andCellular Properties
Chapter 3 Cytotoxic T Lymphocytes: TargetCell Recognition and Binding
vii
1
29
53
Chapter 4 Cytotoxic T Lymphocytes: Target Cell Killing: Cellular Parameters 71
Chapter 5 Cytotoxic T Lymphocytes: Target Cell Killing: Molecular mechanisms
Chapter 6 InnateCellmediated Immunity
Chapter 7 The Role ofCytotoxicityin Allograft RejectionInVivo
Chapter 8 Cytotoxicity in Immune Defenses Against Intracellular Parasites
95
125
159
179
vi
Chapter 9 KillerCells andCancer
Chapter 10 Autoimmunity
Chapter 11 Homeostasis, Memory and CTL Vaccines
References
Index
201
217
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353