107 Pages
English

You can change the print size of this book

Non-Alcoholic Fatty Liver Disease, An Issue of Clinics in Liver Disease, E-Book

-

Gain access to the library to view online
Learn more

Description

Due to the current obesity epidemic, non-alcoholic fatty liver disease (NAFLD) is prevalent in a significant portion of the United States patient population. It is being increasingly recognized that NAFLD affects both adults and children and can progress to end stage liver disease with resultant cirrhosis, portal hypertension, and hepatocellular carcinoma. In addition, several extrahepatic conditions may be linked to NAFLD including cardiovascular disease, insulin requiring and type 2 diabetes mellitus, obstructive sleep apnea, colonic adenomas, hyperuricemia, vitamin D deficiency, hyperferritinemia, pancreatic steatosis, hypothyroidism, and polycystic ovarian syndrome. Therapies for NAFLD are evolving rapidly. This issue will analyze patient demographics, risk factors, pathophysiology, patient presentation, and treatments for NAFLD.

Subjects

Informations

Published by
Published 09 August 2016
Reads 0
EAN13 9780323416979
Language English
Document size 1 MB

Legal information: rental price per page 0.0330€. This information is given for information only in accordance with current legislation.

Non-Alcoholic Fatty Liver
Disease
Clinics in Liver Disease
EDITOR
Paul J. Gaglio, MD, FACP, AGAF
Columbia University Medical Center, Columbia University College of Physicians and
Surgeons, Center for Liver Disease and Transplantation, NY Presbyterian
HospitalColumbia University Medical Center, New York, NY, USA
CONSULTING EDITOR
Norman Gitlin

Clinics Review Articles

www.liver.theclinics.com

May 2016 • Volume 20 • Number 2Table of Contents
Cover image
Title page
Copyright
Contributors
Consulting Editor
Editor
Authors
Forthcoming Issues
Forthcoming Issues
Recent Issues
Preface. Nonalcoholic Fatty Liver Disease
Epidemiology of Nonalcoholic Fatty Liver Disease and Nonalcoholic Steatohepatitis
in the United States and the Rest of the World
Key points
Background
Nonalcoholic fatty liver disease/nonalcoholic steatohepatitis diagnosis
Nonalcoholic fatty liver disease/nonalcoholic steatohepatitis incidence
Nonalcoholic fatty liver disease/nonalcoholic steatohepatitis worldwide prevalence
by continent
Risk factors for nonalcoholic fatty liver disease/nonalcoholic steatohepatitis
Summary
ReferencesThe Prevalence and Pathobiology of Nonalcoholic Fatty Liver Disease in Patients of
Different Races or Ethnicities
Key points
Introduction
Differences in the metabolic syndrome based on race or ethnicity
Summary
References
The Metabolic Syndrome and Its Influence on Nonalcoholic Steatohepatitis
Key points
Introduction
Definitions of the metabolic syndrome and nonalcoholic steatohepatitis
Epidemiology of the metabolic syndrome and nonalcoholic steatohepatitis
Pathogenesis of the metabolic syndrome and nonalcoholic steatohepatitis
Role of diet
Role of genetic factors
Role of adipokines
Correlation between the metabolic syndrome and nonalcoholic steatohepatitis
Treatment
Prognosis
Summary
References
Nonalcoholic Fatty Liver Disease: Lipids and Insulin Resistance
Key points
Introduction
Fatty acids, triglycerides, and nonalcoholic fatty liver disease pathophysiology
Long-chain fatty acid transport in specific disease models
Obesity-related liver disease: hepatic steatosis and steatohepatitis
Future prospects
ReferencesNonalcoholic Fatty Liver Disease and the Gut Microbiome
Key points
Introduction
Gut microbiota promotes the onset of nonalcoholic fatty liver disease
Gut microbiota participates to the severity of nonalcoholic fatty liver disease
How to modulate gut microbiota to improve nonalcoholic fatty liver disease
Summary
References
Clinical Presentation and Patient Evaluation in Nonalcoholic Fatty Liver Disease
Key points
Definitions
Why do we need to diagnose nonalcoholic fatty liver disease?
Fibrosis as a predictor of mortality: who with nonalcoholic fatty liver disease is at
risk of dying?
Liver biopsy
Serologic tests for diagnosing hepatic fibrosis in nonalcoholic fatty liver disease
Imaging tests for diagnosing hepatic fibrosis in nonalcoholic fatty liver disease
Summary
References
Histology of Nonalcoholic Fatty Liver Disease and Nonalcoholic Steatohepatitis in
Adults and Children
Key points
Introduction
Importance of liver biopsy in nonalcoholic fatty liver disease
Pathology of nonalcoholic fatty liver disease and nonalcoholic steatohepatitis
Nonalcoholic fatty liver disease and nonalcoholic steatohepatitis in children and
adolescents
Grading, staging, and scoring in nonalcoholic fatty liver disease and nonalcoholic
steatohepatitis
Sample and observer variability
Histology-based natural history studiesSummary
References
Progression and Natural History of Nonalcoholic Fatty Liver Disease in Adults
Key points
Introduction
Liver disease progression in simple steatosis and nonalcoholic steatohepatitis
Risk factors for disease progression in simple steatosis and nonalcoholic
steatohepatitis
Liver disease progression in nonalcoholic steatohepatitis–related cirrhosis
Hepatocellular carcinoma in nonalcoholic fatty liver disease
Summary
References
The Progression and Natural History of Pediatric Nonalcoholic Fatty Liver Disease
Key points
Introduction
Summary
References
Effect of Weight Loss, Diet, Exercise, and Bariatric Surgery on Nonalcoholic Fatty
Liver Disease
Key points
Introduction
Weight loss
Dietary interventions
Low carbohydrate and low fat diets
Fructose
Polyunsaturated fatty acids
Exercise
Diet and exercise
Bariatric surgery
SummaryReferences
Current Pharmacologic Therapy for Nonalcoholic Fatty Liver Disease
Key points
Introduction
Current treatment options
Potential therapies for nonalcoholic fatty liver disease
Summary
References
Emerging Therapies for Nonalcoholic Fatty Liver Disease
Key points
Introduction
Challenges in drug development for nonalcoholic steatohepatitis
New drugs under study for treatment of nonalcoholic steatohepatitis
Summary
References
Extrahepatic Complications of Nonalcoholic Fatty Liver Disease
Key points
Cardiovascular disease
Evaluation of subclinical cardiovascular risk
Clinical manifestations and effect on cardiovascular disease
Pathophysiology
Diabetes mellitus
Pathogenesis
Chronic kidney disease
Pathogenesis
Extrahepatic malignancy
Colorectal cancer
Endocrinopathies
Polycystic ovarian syndromeHypothyroidism
Osteoporosis
Obstructive sleep apnea
Cholesteryl ester storage disease
Summary
References
Nonalcoholic Fatty Liver Disease and Liver Transplantation
Key points
Introduction
Nonalcoholic fatty liver disease and pre liver transplant considerations
Nonalcoholic fatty liver disease and post liver transplant considerations
Approach to recurrence of nonalcoholic fatty liver disease and nonalcoholic
steatohepatitis after liver transplantation
ReferencesCopyright
Elsevier
1600 John F. Kennedy Boulevard • Suite 1800 • Philadelphia, Pennsylvania, 19103-2899
http://www.theclinics.com
CLINICS IN LIVER DISEASE Volume 20, Number 2
May 2016 ISSN 1089-3261, ISBN-13: 978-0-323-41696-2
Editor: Kerry Holland
Developmental Editor: Meredith Clinton
© 2016 Elsevier Inc. All rights reserved.
This periodical and the individual contributions contained in it are protected under
copyright by Elsevier, and the following terms and conditions apply to their use:
Photocopying
Single photocopies of single articles may be made for personal use as allowed by
national copyright laws. Permission of the Publisher and payment of a fee is required
for all other photocopying, including multiple or systematic copying, copying for
advertising or promotional purposes, resale, and all forms of document delivery.
Special rates are available for educational institutions that wish to make photocopies
for non-profit educational classroom use. For information on how to seek permission
visit www.elsevier.com/permissions or call: (+44) 1865 843830 (UK)/(+1) 215 239 3804
(USA).
Derivative Works
Subscribers may reproduce tables of contents or prepare lists of articles including
abstracts for internal circulation within their institutions. Permission of the Publisher
is required for resale or distribution outside the institution. Permission of the
Publisher is required for all other derivative works, including compilations and
translations (please consult www.elsevier.com/permissions).
Electronic Storage or Usage
Permission of the Publisher is required to store or use electronically any material
contained in this periodical, including any article or part of an article (please consult
www.elsevier.com/permissions). Except as outlined above, no part of this publication
may be reproduced, stored in a retrieval system or transmitted in any form or by any
means, electronic, mechanical, photocopying, recording or otherwise, without prior
written permission of the Publisher.
NoticeNo responsibility is assumed by the Publisher for any injury and/or damage to
persons or property as a matter of products liability, negligence or otherwise, or from
any use or operation of any methods, products, instructions or ideas contained in the
material herein. Because of rapid advances in the medical sciences, in particular,
independent verification of diagnoses and drug dosages should be made.
Although all advertising material is expected to conform to ethical (medical)
standards, inclusion in this publication does not constitute a guarantee or
endorsement of the quality or value of such product or of the claims made of it by its
manufacturer.
Clinics in Liver Disease (ISSN 1089-3261) is published quarterly by Elsevier Inc., 360
Park Avenue South, New York, NY 10010-1710. Months of issue are February, May,
August, and November. Business and Editorial Offices: 1600 John F. Kennedy Blvd.,
Ste. 1800, Philadelphia, PA 19103-2899. Customer Service Office: 3251 Riverport Lane,
Maryland Heights, MO 63043. Periodicals postage paid at New York, NY and
additional mailing offices. Subscription prices are $275.00 per year (U.S. individuals),
$100.00 per year (U.S. student/resident), $453.00 per year (U.S. institutions), $395.00
per year (international individuals), $200.00 per year (international student/resident),
$562.00 per year (international instituitions), $340.00 per year (Canadian individuals),
$200.00 per year (Canadian student/resident), and $562.00 per year (Canadian
institutions). Foreign air speed delivery is included in all Clinics subscription prices.
All prices are subject to change without notice. POSTMASTER: Send address
changes to Clinics in Liver Disease, Elsevier Health Sciences Division, Subscription
Customer Service, 3251 Riverport Lane, Maryland Heights, MO 63043. Customer
Service: Telephone: 1-800-654-2452 (U.S. and Canada); 314-447-8871 (outside U.S. and
Canada). Fax: 314-447-8029. E-mail: journalscustomerservice-usa@elsevier.com (for
print support); journalsonlinesupport-usa@elsevier.com (for online support).
Reprints. For copies of 100 or more of articles in this publication, please contact the
Commercial Reprints Department, Elsevier Inc., 360 Park Avenue South, New York,
NY 10010-1710. Tel.: 212-633-3874; Fax: 212-633-3820; E-mail: reprints@elsevier.com.
Clinics in Liver Disease is covered in MEDLINE/PubMed (Index Medicus), Science
Citation Index Expanded, Journal Citation Reports/Science Edition, and Current
Contents/Clinical Medicine.
Printed in the United States of America.