Phospholipid Metabolism in Apoptosis

Phospholipid Metabolism in Apoptosis

-

English

Description

The last few years have witnessed an explosion of both interest and knowledge about apoptosis, the process by which a cell actively commits suicide. It is now well recognised that apoptosis is essential in many aspects of normal development and is required for maintaining tissue homeostasis. The molecular mechanisms of apoptosis are presently unknown and the subject of focused research effort. It is clear that cell membrane structure and properties play an early part in the induction process. There is increasing evidence that the arrangement of polar lipids in the membrane lipid matrix is an important factor coupled with the homeostatic mechanisms responsible for preserving membrane lipid composition and asymmetry. Changes in membrane permeability are also likely to be involved, possibly as a direct consequence of disturbances in the lipid bilayer matrix.
The purpose of this volume is to examine the involvement of membrane lipids in early events of apoptosis. In particular, the role of phospholipids in mitochondrial permeability, membrane lipid asymmetry, and sphingolipid and phospholipid signalling processes in early apoptotic events are reviewed by current researchers in these fields.

Subjects

Informations

Published by
Published 01 January 1983
Reads 6
EAN13 0306479311
License: All rights reserved
Language English

Legal information: rental price per page €. This information is given for information only in accordance with current legislation.

Report a problem
Contents
Lipid Metabolism and Release of Cytochrome c from Mitochondria VOLKERLEHMANNand VLADIMIRSHATROV
Interaction between Cytochrome c and Oxidized Mitochondrial Lipids YOSHIHIROSHIDOJI, SADAAKIKOMURA, NOBUKOOHISHI, and KUNIOYAGI
Plasma Membrane Phospholipid Asymmetry PETERJ. QUINN
Apoptosis by Phosphatidylserine in Mammalian Cells KAZUOEMOTOand MASATOUMEDA
Phosphatidylserine Peroxidation during Apoptosis Y.Y. TYURINA,V.A. TYURIN,S.X. LIU,C.A. SMITH, A.A. SHVEDOVA,N.F. SCHORand V.E. KAGAN
Role of Nitric Oxide and Membrane Phospholipid Polyunsaturation in Oxidative Cell Death C. PATRICKBURNS,ERICE. KELLEY,BRETTA. WAGNER, and GARRYR. BUETTNER
Oxidized LDLinduced Apoptosis HERVÉBENOIST,ROBERTSALVAYRE,and ANNENÈGRESALVAYRE
xv
l
19
39
61
79
97
123
xvi
Induction of Apoptosis by Redoxcycling Quinones KARINÖLLINGERand KATARINAKÅGEDAL
Apoptosis Induced by Ionizing Radiation CRISTIANOFERLINI,RAFFAELEDAMELIO, and GIOVANNISCAMBIA
Ceramidases in the Regulation of Ceramide Levels and Function SAMERELBAWAB, CUNGUI MAO, LINA M. OBEID, and YASUFH A. ANNUN
Contents
151
171
187
Effect of Ceramides on Phospholipid Biosynthesis and Its Implication for Apoptosis207 ARIEB. VAANDRAGERand MARTINHOUWELING
Acid Sphingomyelinasederived Ceramide Signaling in Apoptosis ERICHGULBINSand RICHARDKOLESNICK
Cellular Signaling by Sphingosine and Sphingosine 1phosphate SUSANPYNE
Ceramide in Regulation of Apoptosis JEANPIERREJAFFRÉZOU, GUYLAURENTT, and HIERRYLEVADE
Lipid Signaling in CD95mediated Apoptosis ALESSANDRARUFINIand ROBERTOTESTI
Phosphatidylinositol 3kinase, Phosphoinositides and Apoptosis GABRIELLASARMAY
Index
229
245
269
285
309
335