Protein Quality Control in Neurodegenerative Diseases

Protein Quality Control in Neurodegenerative Diseases

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English

Description

The health of the proteome depends upon protein quality control to regulate the proper synthesis, folding, translocation, and clearance of proteins. The cell is challenged constantly by environmental and physiological stress, aging, and the chronic expressions of disease associated misfolded proteins. Substantial evidence supports the hypothesis that the expression of damaged proteins initiates a cascade of molecular events that leads to Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, Huntington's disease, and other diseases of protein conformation.

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Published 13 December 2012
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EAN13 9783642279287
Language English

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Protein Quality Control in Neurodegenerative Diseases