Signal Transduction by Reactive Oxygen and Nitrogen Species: Pathways and Chemical Principles

Signal Transduction by Reactive Oxygen and Nitrogen Species: Pathways and Chemical Principles

-

English

Description

Since publication of the first edition of this book, (then entitled Oxidative Stress and Signal Transduction), reactive oxygen and nitrogen species (ROS/RNS) have taken center stage in the field of signal transduction. Our understanding of the many signaling pathways that coordinate the cell's response to its environment has made significant strides in the last ten years and evidence is now mounting that the ROS and RNS enzymatically produced by the cells are required for different aspects of the cycle of life from growth to apoptosis. The enzymes responsible for the production of ROS and RNS have been unraveled and the participation of these species in numerous signaling pathways has been documented. The next step is now to identify the targets of ROS and RNS and the mechanisms by which they alter their activity in the affected signaling pathway and significant progress has already been made.
This exciting area of research will benefit from the pulling together of the work from hard-core chemists and free radical aficionados along with that of signaling enthusiasts and cell biologist devotees. This was the idea behind the conception of this new book. Signal Transduction by Reactive Oxygen and Nitrogen Species: Pathways and Chemical Principles provides relevant chemistry that can be applied across signaling systems and summarizes the current state of knowledge in the area of redox signaling, including controversies when they exist and future directions.
ROS and RNS have been implicated in inflammation, aging and cancer and their novel role in signal transduction may offer new clues to their participation in these processes. This volume should be of great interest to researchers involved in a large range of scientific fields from biochemistry and physiology to pharmacology.

Subjects

Informations

Published by
Published 01 January 1983
Reads 4
EAN13 0306484129
License: All rights reserved
Language English

Legal information: rental price per page €. This information is given for information only in accordance with current legislation.

Report a problem
Contents
Contributors
Acknowledgements
Preface
Part I:
1
2
3
4
5
Chemical Principles in Reactive Oxygen and Nitrogen Signaling
Redox State and Redox Environment in Biology Freya Q. Schafer and Garry R. Buettner Sulfur and Selenium Catalysis as Paradigms for Redox Regulations Leopold Flohé Thiols of Thioredoxin and Glutaredoxin in Redox Signaling Arne Holmgren Reactivity and Diffusivity of Nitrogen Oxides in Mammalian Biology Jack R. Lancaster, Jr. Bacterial Peroxiredoxins Leslie B. Poole
Part II: Redox Signaling
6
7
The Nox Enzymes and the Regulated Generation of Reactive Oxygen Species Rebecca S. Arnold and J. David Lambeth NO Synthesis and Nos Regulation Ulrich Forstermann, Huige Li, Petra M. Schwarz and Hartmut Kleinert
vii
xiii
xv
1
15
33
53
80
102
119
vi
8
9
10
11
12
13
14
SNitrosothiols in Cell Signaling Joseph Loscalzo Hydrogen Peroxide as Intracellular Messenger: Identifcation of Protein Tyrosine Phosphatases and PTEN as Target Sue Goo Rhee, SeungRock Lee, KapSeok Yang, Jaeyul Kwon, and Sang Won Kang 4Hydroxynonenal Signaling Giuseppe Poli, Gabriella Leonarduzzi and Elena Charpotto Ceramide Signaling under Oxidative Stress Tzipora Goldkorn, Tommer Ravid and Edward A Medina Map Kinases in Redox Signaling Atsushi Matsuzawa, Hideki Nishitoh, Kohsuke Takeda and Hidenori Ichijo Activation of Prostaglandin Biosynthesis: Peroxynitrite vs Hydroperoxides Lisa Landino Phylogenetic Conservation of the Nrf2Keap1 Signaling System Xue Zhang, Mark Garfinkel, and Douglas Ruden
Part 3 Physiology and Pathophysiology
15
16
17
18
19
20
The NOCytochrome C Oxidase Signaling Pathway; Mechanisms and Biological Implications Sruti Shiva, AnnaLiisa Levonen, Maria Cecilia Barone, and Victor M. DarleyUsmar The Concept of Compartmentalization in Signaling By Reactive Oxygen Species Victor J. Thannickal and Barryl Fanburg Role of Mitochondrial Oxygen and Nitrogen Reactive Species in Signaling Cecilia Giulivi and Merry Jo Oursler Redox Regulation of Gene Expression: Transcriptional Induction of Heme Oxygenase1 Timothy P. Dalton, Lei He, Howard G. Shertzer and Alvaro Puga Apoptosis Mechanisms Initiated by Oxidative Stress Irene E Kochevar Reactive Oxygen and Nitrogen Species in the Production of Congenital Malformations by Known Teratogenic Agents and Maternal Conditions Antonio F Machado, William J. Scott and Michael D. Collins
Index
155
167
180
194
223
237
256
275
291
311
333
365
379
407