CELTIC RELIGION The Ancient Celts

CELTIC RELIGION The Ancient Celts

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  • expression écrite - matière potentielle : by classical authors
  • cours - matière potentielle : the year
  • expression écrite
CELTIC RELIGION The Ancient Celts The Celts originated, as far as is known, in the eighth century BC in Eastern Europe - probably Hungary and Czechoslovakia - from where they migrated across Europe and were known as “Galates” by the Greeks and “Gauls” by the Romans. The first mention in Classical writing that has survived dates back to about 500BC. However, most of the references to this elusive people are of later date.
  • such temple
  • original megalith builders
  • wooden dolls
  • arrogant assumption of celtic religion as a primitive reflection
  • gaul
  • god of war
  • bronze
  • celtic
  • forest
  • people

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Course5.6InsilicoADME&Predictive Toxicology711May2012FacultyofPharmaceuticalSciences,UniversityofCopenhagenHomeAssignment(CaseStudiesandCoursequestions)nd Tobecompletedbythe22June2012
InsilicoADME&PredictiveToxicologyCourse:Keyquestionstobetackledbythecourse
ThedrugdiscoveryanddevelopmentprocesswithspecialžfocusonADME/ToxžAbsorptionanddistributionfromaPKpointofviewCriticalanalysisofexperimentaldatažPredictionofabsorptionanddistributionžžPhaseIandIImetabolismThecytochromeP450enzymesžPredictionofmetabolismClassificationPredictionofmetabolismSiteofmetabolismžPredictionoftoxicity(e.g.genotoxicity,phospholipidosis,žhERGetc.)GenomiceffectsonmetabolismandtoxicityžžDifferentQSARsystemsavailable
Introduction TheInsilicoADME&PredictiveToxicologycourseispartofthenewEuropeanMastersdegreeforAdvancedSafetySciencesforMedicinesdesignedbySafeSciMETaspartoftheEuropeanInnovativeMedicinesInitiative(IMI).SafeSciMETisauniquepanEuropeannetworkofacademicsandpharmaceuticalindustrywhohavecometogethertoestablishacomprehensiveSafetySciencesModularEducation&TrainingprogrammecoveringallaspectsofsafetyindrugdevelopmenttoensureEuropeanDrugSafetyScientistsinthepharmaceuticalindustry,regulatoryauthoritiesandacademiaareattheforefrontoftheirfield.WhyjointhecourseinInsilicoADME&PredictiveToxicology?Theuseofinsilicomethodsinthedrugdiscoveryanddevelopmentprocessbecomesmoreandmoreimportant.Predictiveinsilicomethodsaregettingconsiderablemorereliable,theycoverabroaderspectrumofpredictiveendpoints,andtheyaregettingeasiertousefornonspecialists.Reliablepredictivemodelsmayreplacecostlyexperimentsandtherebycontributetoacostreductionofthedrugdiscoveryanddevelopmentprocess.Furthermore,insilicomethodsmakesitpossibletohandleandevaluatelargedatasetsandtherebycoveringthechemicalandpharmacologicalspacemoreextensively.CourseObjectivesThiscourseconsistsof5daysinCopenhagenwithlectures,practicalexercises,groupworkanddiscussionsfollowedbyaweekathomededicatedtoanindividualassignment.Thus,thetotalcoursewillprovidetheparticipantswithacomprehensiveoverviewofinsilicomethodsinthedrugdiscoveryanddevelopmentprocess,whereinsilicomethodscanbeused,andwhataretheirstrengthsandweaknesses.Furthermore,youwillgethandsonexperiencewithseveralpredictiveinsilicomethodsaswellasanintroductiontotheprinciplebehindthemethods.Duringtheindividualassignmentyouwillgettheopportunitytofocusfurtheronmethodsrelevantforyourinterestandemployment.Forkeytopicscoveredatthecourse,seebackofbrochure.
TargetGroup SafeSciMETstudents,academicsandworkersinthepharmaceuticalindustryandregulatoryauthoritieswhoneedabroadcomprehensiveunderstandingofthedrugdevelopmentprocesswithparticularemphasisonsafety.LearningoutcomesThecourseprovidestheparticipantswithanintroductionandhandsonexperiencewithinsilicomethodsforpredictionofvariousADME/Toxrelevantendpoints.Morespecifically,participantswillbeableto:UsewebbasedtoolsforpredictionofsimpleADME/Toxendpointslikedruglikeness,solubility,absorption,genotoxicity,phospholipidosisetc.UsepurposedevelopedcomputationaltoolsforpredictionofcomplexADME/Toxendpointslikepredictionofmetabolism(classification)andsiteofmetabolismUnderstandtheprinciplesbehindthemostcommonlyusedtypesofpredictivemethodsExploreandunderstandthediversityofalargedataset
CourseProgrammeTheSyllabusAsyllabuscontaininganintroductorychapter,lecturehandouts,listofabbreviations, definitionsandreadingmaterialswillbeprovidedbythecourseleader14dayspriortothe course.Thematerialforthehomeassignmentwillbeprovidedduringthefirstweekofthe course.
AssessmentTheassessmentisbasedona2hourwrittenexaminationonthelastdayofthecourseandontheevaluationofthehomeassessment
TypeAssessors(s)ExamaidsCourseadministrator:
Thepurposeoftheexaminationistotestthattheexamineehasabroadknowledgeandcomprehensionofwhereinthedrugdiscoveryanddevelopmentprocessinsilicomethodsmaybeapplied,strengthsandlimitationsassociatedwithdifferenttypesofpredictivemethods,andspecificexperienceswithsomerepresentativeinsilicomethods
CourseDirectorsAllwrittenexamaidsareallowedProfessorFlemmingSteenJørgensen DepartmentofMedicinalChemistryFacultyofPharmaceuticalSciencesUniversityofCopenhagenUniversitetsparken2DK2100Copenhagen,DenmarkPhone:+4535336378Mail:fsj@farma.ku.dk
PracticalInformationCourseCredits:3ECTScreditsLevel:Master’slevel(secondcyclehighereducation)CourseDates: 711May2012Location:TheFacultyofPharmaceuticalSciences,UniversityofCopenhagen,Universitetsparken2,DK2100Copenhagen,DenmarkTeachingmethods:Lectures,practicalexercises,groupwork,presentationsanddiscussions.Inordertoprovidetheparticipantswithpracticalexperiencewithinsilicopredictivemethods,approximatelyhalfofthecoursewillbepracticalexercisesandgroupwork.StudentWorkload:Preparation:10hoursCourse:38hoursExamination:2hoursAssignment:40Total:90hoursCourseFee:2,500Euro—750Euro(dependentoncategoryofstudent)(pleasevisitwww.SafeSciMET.eu.Howtoapplyformoreinformation)Applicationdeadline:7April2012CourseCapacity:24participantsLanguage:TheofficiallanguageofthecourseisEnglish.NosimultaneoustranslationswillbeprovidedCoursenotes:Notes(literature)usedinthecourseCourseaccreditation:ThecoursemeetsthecriteriaforcontinuousprofessionalDevelopment(CPD)diplomas,anditwillbepartofa(forthcomingEuropean)MastersofAdvancedSafetySciencesdegree.Moreinformationcanbeobtainedthroughourwebsite:http://www.SafeSciMET.eu
CourseLeaders ProfessorFlemmingSteenJørgensenDepartmentofMedicinalChemistry,FacultyofPharmaceuticalSciences,UniversityofCopenhagen,DenmarkDr.AlexanderAmbergR&DDSAR/PreclinicalSafetyFrankfurt,SanofiAventisDeutschlandGmbH,GermanyCourseTeachersProfessorGerhardEckerPharmacoinformaticsResearchGroup,DepartmentofMedicinalChemistry,UniviversityofVienna,AustriaProfessorChrisOostenbrinkIntituteofMolecularModelingandSimulation,UniversityofNaturalResourcesandLifeSciences,Vienna,AustriaAssociateProfessorLarsOlsenDepartmentofMedicinalChemistry,FacultyofPharmaceuticalSciences,UniversityofCopenhagen,DenmarkDr.ArmelStockisGlobalExploratory,tneBCUveDepmloPharmaS.A.,Brussels,eBgluimDr.GrahamWishartDrugDispositionEurope,LillyUK,Windlesham,UnitedKingdomDr.UlfNorinderAstraZenecaResearch&Development,Södertälje,Sweden
REGISTRATIONPleasevisitwww.safescimet.eutoregister.Onthehomepage,pleasegotoHowtopplyandsignup:ForMScofAdvancedSafetyCourses ForContinuingProfessionalDevelopment(CPD) ForSinglecourses
Youwillbenotifiedthatyourregistrationhasbeenreceived
Theclosingdatetoregisterforthiscourseis7 April2012
Pleasenotethatthenumberofparticipantsislimitedto24.Itishighlyadvisabletosendinyourregistrationformassoonaspossible.Registrationwillbemadeonafirstcomefirstservedbasis
TRANSPORTThe course takes place in central Copenhagen, 12 km from the airport and 5 km from the city center. Several bus lines serve the course site.
ACCOMMODATIONHotels can be arranged individually via www.visitcopenhagen.dk
CANCELLATIONCancellation of a pre-registered student is possible, upon written notice by 20 April 2012. Before that date the Course fee will be refunded except for an administrative fee of EUR 75. After that date, no refunds can be made for cancellations