A Model of Pattern Heterogeneity for Inferring Phylogenetic Trees and

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A Model of Pattern-Heterogeneity for Inferring Phylogenetic Trees and Investigating Sequence Evolution Mark Pagel and Andrew Meade Reading University

  • inferring phylogenetic

  • rate matrix

  • model best

  • phylogenetic inference

  • homogeneous model

  • sites according

  • qac qag qat

  • allow rates


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A Model of Pattern-Heterogeneity for Inferring Phylogenetic Trees and Investigating Sequence Evolution
Mark Pagel and Andrew Meade Reading University
m.pagel@rdg.ac.uk
30000000000
25000000000
20000000000
15000000000 No. of nucleotides
10000000000
5000000000
0
1980
1982
The growth of GenBank
1984
1986
1988
No. of nucleotides No. of gene s
1990
1992
1994
1996
1998
2000
2002
25000000
20000000
15000000
10000000
5000000
2004
0
No. of genes
6000
5000
4000
3000
2000
The use of molecular phylogenies in biological research
molecular phylogeny coalescent / genealogy
phyl1o0g00enies:cumulative frequency
0
1980
1982
1984
1986
1988 1990 Year
1992
1994
1996
1998
2000
100
75
50
25
0
2002
genealogies: cumulative frequency