Basic Concepts Signaling Pathways
39 Pages
English

Basic Concepts Signaling Pathways

-

Downloading requires you to have access to the YouScribe library
Learn all about the services we offer

Description

Niveau: Supérieur, Master, Bac+4
Cell Signaling Basic Concepts Signaling Pathways Pr. Jean-Paul Borg I N S T I T U T PAOLI-CALMETTES PR O V E N C E - A L P E S - C Ô T E D ' A Z U R CENTRE REGIONAL DE LUTTE CONTRE LE CANCER

  • cell communication

  • centre regional de lutte contre le cancer

  • signaling pathways

  • paoli-calmettes pr


Subjects

Informations

Published by
Reads 6
Language English
Document size 2 MB
Cell Signaling
BasicConcepts SignalingPathways
Pr. Jean-Paul Borg
I N S T I T U T CENTRE REGIONAL DE LUTTE CONTRE LE CANCER PAOLI-CALMETTES P R O V E N C E - A L P E S - C Ô T E D ' A Z U R
Introduction
- Cell communication: a fundamental feature of pluricellular organisms
- Responses: cell proliferation, cell migration, apoptosis, cell differentiation
- Short or long distance
- Ligands: peptides, proteines, gaz
- Pathologies
Introduction
Principles of information transmission
Goalofsignalingpathwaysistoensureanappropriate reactiontothetypeandstrengthofanextracelualr stimulus
growth
proliferation
death
necrosis apoptosis
Environmental input
processing
reaction
EFFECTOR FUNCTIONS
movement
Generate new information nssoisnimtoarenru menesssreg
A Model of Receptor-mediated Signal Transduction
SPECIFICITY
INTEGRITY
ECONOMY
X
Y
Z
Signal
Receptor
Protein -1
Protein -2
Protein -n
otein Network
Effectors(e.g.,enzymes,transcriptionfactors,etc)
Biological Responses
Messengers
Signaling Cascades
Amplification of the signal
1 ligand
1 receptor
n
1. 10 intracellular messengers
synaptic
Modalities of transmission
paracrine
endocrine
distance
diffusion
decay
Modalities of transmission
SPECIFICITY
Ligands and receptors