M1 Cell Signaling2007 2008partII
33 Pages
English

M1 Cell Signaling2007 2008partII

-

Downloading requires you to have access to the YouScribe library
Learn all about the services we offer

Description

Niveau: Supérieur, Master, Bac+4
PH Domains

  • aa - ligands

  • ptb domain

  • binding specificities

  • terminal specificity - irs


Subjects

Informations

Published by
Reads 7
Language English
Document size 1 MB
PH Domains
Activation of
Akt
----
PTB
~ 100 AA ligands: pY or not pY N-terminal specificity IRS-1, Shc
PTB
domain
SH2
PDZ domains
are widely
distributed
in genomes
Nourry
et al., 2003
Binding
specificities
SH3
PDZ PTB
WW
PxxP
(p)YxxM
NPxY(p)
PPxY
of
protein
interaction domains
S/TxV orΨxΨ
Some important signaling pathways
Receptors coupled to heterotrimeric G proteins (GPCR)
Constitutive association
GTP dependant-dissociation
GTP dependante association
GTP dependante activation
Dissociation after hydrolysis of GTP