Analysis of the variety of human genome loci associated with fast and long–lasting adaptation to the load of physical activity ; Žmogaus genomo sričių, susijusių su greita ir ilgalaike adaptacija fiziniam krūviui, įvairovės analizė

-

English
55 Pages
Read an excerpt
Gain access to the library to view online
Learn more

Description

VILNIUS UNIVERSITY Valentina Ginevičien÷ ANALYSIS OF THE VARIETY OF HUMAN GENOME LOCI ASSOCIATED WITH FAST AND LONGLASTING ADAPTATION TO THE LOAD OF PHYSICAL ACTIVITY Summary of doctoral dissertation Biomedical sciences, biology (01 B) Vilnius, 2010 The work was carried out at the Department of Human and Medical Genetics, Faculty of Medicine, Vilnius University during years 2006#2010 Principal supervisor: Prof. Dr. Habil. Vaidutis Kučinskas (Vilnius University, biomedical sciences, biology – 01 B) The dissertation is defended at Vilnius University, Academic Board of Examiners in Biology: Chairman: Prof. Dr. Habil. Juozas Rimantas Lazutka (Vilnius University, biomedical sciences, biology – 01 B) Members: Prof. Dr. Alvydas Juocevičius (Vilnius University, biomedical sciences, medicine – 07 B) Prof. Dr. Habil. Limas Kupčinskas (Kaunas University of Medicine, biomedical sciences, medicine – 07 B) Prof. Dr. Habil. Albertas Skurvydas (Lithuanian Academy of Physical Education, biomedical sciences, biology – 01 B) Prof. Dr. Gražina Slapšyt÷ (Vilnius University, biomedical sciences, biology – 01 B) Opponents: Prof. Dr. Algirdas Utkus (Vilnius University, biomedical sciences, medicine – 07 B) Prof. Dr. Algimantas Paulauskas (Vytautas Magnus University, biomedical sciences, biology – 01 B) thThesis defence will take place at 11 p.m.

Subjects

Informations

Published by
Published 01 January 2010
Reads 26
Language English
Report a problem
VILNIUS UNIVERSITY       Valentina Ginevičien÷     ANALYSIS OF THE VARIETY OF HUMAN GENOME LOCI ASSOCIATED WITH FAST AND LONGLASTING ADAPTATION TO THE LOAD OF PHYSICAL ACTIVITY    Summary of doctoral dissertation Biomedical sciences, biology (01 B)        Vilnius, 2010  
The work was carried out at the Department of Human and Medical Genetics, Faculty of Medicine, Vilnius University during years 2006#2010  Principal supervisor: Prof. Dr. Habil.Vaidutis Kučinskas sciences,(Vilnius University, biomedical biology – 01 B)  The dissertation is defended at Vilnius University, Academic Board of Examiners in Biology:  Chairman: Prof. Dr. Habil.Juozas Rimantas Lazutka(Vilnius University, biomedical sciences, biology – 01 B)  Members: Prof. Dr.Alvydas Juocevičius(Vilnius University, biomedical sciences, medicine – 07 B)  Prof. Dr. Habil.Limas Kupčinskas(Kaunas University of Medicine, biomedical sciences, medicine – 07 B)  Prof. Dr. Habil.Albertas Skurvydas(Lithuanian Academy of Physical Education, biomedical sciences, biology – 01 B)  Prof. Dr.Gražina Slapšyt÷(Vilnius University, biomedical sciences, biology – 01 B)  Opponents: Prof. Dr.Algirdas Utkus(Vilnius University, biomedical sciences, medicine – 07 B)  Prof. Dr.Algimantas Paulauskas(Vytautas Magnus University, biomedical sciences, biology – 01 B)    Thesis defence will take place at 11 p.m. on October 8th, 2010 in Conference Hall of Vilnius University Hospital Santariskiu Klinikos.  Address:Santariškiu street 2, LT#2021 Vilnius, Lithuania Phone: +370#5#2365197, Fax: +370#5#2365199     The abstract of the thesis has been sent on the 20thAugust, 2010. The thesis is available at Vilnius University Library.  
 
2
 
VILNIAUS UNIVERSITETAS       Valentina Ginevičien÷     ŽMOGAUS GENOMO SRIČIŲ, SUSIJUSIŲ SU GREITA IR ILGALAIKE ADAPTACIJA FIZINIAM KRŪVIUI, ĮVAIROVöS ANALIZö     Daktaro disertacijos santrauka Biomedicinos mokslai, biologija (01 B)         Vilnius, 2010
3
Disertacija rengta 2006 – 2010 metais Vilniaus universiteto Medicinos fakulteto Žmogaus ir medicinin÷s genetikos katedroje  Mokslinis vadovas: Prof. habil. dr.Vaidutis Kučinskas(Vilniaus universitetas, biomedicinos mokslai, biologija – 01 B)  Disertacija ginama Vilniaus universiteto Biologijos mokslo krypties taryboje:  Pirmininkas: Prof. habil. dr.Juozas Rimantas Lazutka(Vilniaus universitetas, biomedicinos mokslai, biologija – 01 B)  Nariai: Prof. dr.Alvydas Juocevičius, (Vilniaus universitetas, biomedicinos mokslai, medicina – 07 B)  Prof. habil. dr.Limas Kupčinskas(Kauno medicinos universitetas, biomedicinos mokslai, medicina – 07 B)  Prof. habil. dr. Skurvydas Albertas kūno kultūros akademija, (Lietuvos biomedicinos mokslai, biologija01 B)  Prof. dr.Gražina Slapšyt÷ universitetas, biomedicinos mokslai, (Vilniaus biologija – 01 B)  Oponentai: Prof. dr.Algirdas Utkus(Vilniaus universitetas, biomedicinos mokslai, medicina – 07 B)   Prof. dr.Algimantas Paulauskas (Vytauto Didžiojo universitetas, biomedicinos mokslai, biologija01 B)   Disertacija ginama viešame doktorantūros komiteto pos÷dyje, kuris įvyks 2010 m. spalio 8 d. 11 val., VšĮ Vilniaus universiteto ligonin÷s Santariškių klinikų konferencijų sal÷je.   Adresas:Santariškių g.2, LT#2021, Vilnius Tel: +370#5#2365197, faksas: +370#5#2365199   Disertacijos santrauka išsiųsta 2010 m. rugpjūčio m÷n. 20 d. Su disertacija galima susipažinti Vilniaus universiteto bibliotekoje.   
 
4
INTRODUCTION Physical capacity is a complex, inheritable and quantitative trait, the phenotypic expression of which could be influenced by both many genes and environmental factors. The determination of genetic factors provides basis for the evaluation of differences in individual physical development as well as in functional capacity. It helps to determine whether an athlete’s body is well fit for a certain activity and predict its athletic development. Many efforts have been directed towards determination of the candidate genes affecting physical capacity (Ahmetov et al., 2009; Bray et al., 2009). Irrespective of a large number of candidate genes (there are 214 autosomal genes and genes that could be associated with quantitative features, 7 genes in the X chromosome and 18 mitochondrial DNA genes known) each candidate gene exercises only a partial influence on the athletic phenotype (Bray et al., 2009). Active search for genes and genetic areas, most adequately reflecting the physical potential of an athlete, is being continued. There is an increasing amount of data concerning the association of gene polymorphism with athletic capacity. It offers the possibility to further investigate gene polymorphisms predisposing an athlete towards specific sporting activities. As a result the most suitable sport can be recommended for an athlete, and the most appropriate personalized training regime is becoming more realistic in an attempt to achieve elite status. Bodily response to physical strain depends on genetic makeup and can significantly impact not only the physical capacity but also health, life quality in senior years and, possibly, one’s life expectancy (Thompson et al., 2006; Lippi et al., 2009).
Aim of the study: To evaluate the features of the genetic variety of Lithuanian athletes according to the DNA markers associated with individual responses to physical strain.  Main tasks of the study: 1. To select genetic markers for the research associated with physical capacity. 2. To research and evaluate the frequency and distribution of the alleles of the candidate genes associated with physical capacity between the sports groups and the control group.
 
5