Annual report : National Institute of Mental Health. Division of Intramural Research Programs
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Annual report : National Institute of Mental Health. Division of Intramural Research Programs

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ANNUAL REPORT Division of Intramural Research Programs National Institute of Mental Health October 1, 1984 September 30, 1985 IVOLUME II PART II INDIVIDUAL PROJECT REPORTS U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES Public Health Service Alcohol, Drug Abuse, and Mental Health Administration National Institute of Mental Health Division of Intramural Research Programs J\ \J ANNUAL REPORT RESEARCH PROGRAMSDIVISION OF INTRAMURAL NATIONAL INSTITUTE OF MENTAL HEALTH (Oi^ J - September 1985October 1, 1984 30, PART IIVOLUME II INDIVIDUAL PROJECT REPORTS -j9o.(:> REPORTANNUAL RESEARCH PROGRAMSDIVISION OF INTRAMURAL NATIONAL INSTITUTE OF MENTAL HEALTH -October 1, 1984 September 30, 1985 TABLE OF CONTENTS -VOLUME II INDIVIDUAL PROJECT REPORTS PART II NEUROPSYCHIATRY BRANCH Consent and Informed ConsentZOl MH 02242-01 NPB Rates in Schizophrenia 985 02243-01 NPB Visual Hallucinations and the VisualZOl MH Cortex in Patients with Schizophrenia... 989 Effect of NeurotoxicZOl MH 02244-01 NPB Behavioral Substances and their Neurochemical Correlates 991 02245-01 Functional Consequences of ExperimentalZOl MH NPB Nerve Lesions 993 02246-01 Post-Traumatic Autoimmune Reaction inZOl MH NPB Peripheral Nerve 997 ZOl MH 02247-01 NPB Prediction of Outcome of Peripheral Nerve -Injuries A Probability Model 1001 ZOl MH 02248-01 NPB Endogenous Substance Extract from Human Binding.Brain Inhibiting Neuroleptic ...

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ANNUAL
REPORT
Division of Intramural Research Programs
National Institute of Mental Health
October 1, 1984 September 30, 1985
IVOLUME II PART II
INDIVIDUAL PROJECT REPORTS
U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES
Public Health Service
Alcohol, Drug Abuse, and Mental Health Administration
National Institute of Mental Health
Division of Intramural Research ProgramsJ\ \J
ANNUAL REPORT
RESEARCH PROGRAMSDIVISION OF INTRAMURAL
NATIONAL INSTITUTE OF MENTAL HEALTH (Oi^ J
- September 1985October 1, 1984 30,
PART IIVOLUME II
INDIVIDUAL PROJECT REPORTS-j9o.(:>REPORTANNUAL
RESEARCH PROGRAMSDIVISION OF INTRAMURAL
NATIONAL INSTITUTE OF MENTAL HEALTH
-October 1, 1984 September 30, 1985
TABLE OF CONTENTS
-VOLUME II INDIVIDUAL PROJECT REPORTS PART II
NEUROPSYCHIATRY BRANCH
Consent and Informed ConsentZOl MH 02242-01 NPB Rates
in Schizophrenia 985
02243-01 NPB Visual Hallucinations and the VisualZOl MH
Cortex in Patients with Schizophrenia... 989
Effect of NeurotoxicZOl MH 02244-01 NPB Behavioral Substances
and their Neurochemical Correlates 991
02245-01 Functional Consequences of ExperimentalZOl MH NPB
Nerve Lesions 993
02246-01 Post-Traumatic Autoimmune Reaction inZOl MH NPB
Peripheral Nerve 997
ZOl MH 02247-01 NPB Prediction of Outcome of Peripheral Nerve
-Injuries A Probability Model 1001
ZOl MH 02248-01 NPB Endogenous Substance Extract from Human
Binding.Brain Inhibiting Neuroleptic ...1005
Ontogeny of Preprocholecystokinin mRNAZOl MH 02249-01 NPB
and Cholecystokinin in the Rat Brain. ...1009
forZOl MH 02250-01 NPB Purification of Messenger RNAs Encoding
Neurotropic Factors in the Rat Brain. ...1013
Distribution of SomatostatinZOl MH 02251-01 NPB Brain
mRNA 1017
ZOl MH 02252-01 NPB Behavioral Pharmacology and
1019Toxi col ogy
02253-01 NPB Brain Tissue Transplantation 1027ZOl MHZOl MH 02254-01 NPB Calcium Channel Inhibitors: Interactions
Dopaminergic Systems -with
Animal Studies 1033
ZOl MH 02255-01 NPB Calcium Channel Inhibitors: Interactions
-with Dopaminergic Systems
Human Studies 1 037
MH 02256-01 NPB Defect Symptoms in Schizophrenia: TheirZOl
Measurement, Correlates and Treatment...1039
ZOl MH 02257-01 NPB Biochemical and Neuroradiologic
in Tardive DyskinesiaAbnormalities 1043
MH 02258-01 Quantitative Neuropathology of AgingZOl NPB
and Neuropsychiatric Disorders 1049
Peripheral and Central CatecholamineZOl MH 02259-01 NPB
Turnover in Depression and
Schizophrenia 1053
ZOl MH 02260-01 NPB Blink Rate in Neuropsychiatric
Di sorders 1 059
02261-01 Clinical Phenomena inZOl MH NPB Schizophrenia:
Quantification in an Effort to
Subtype 1 065
ZOl MH 02262-01 NPB Electroretinography in Schizophrenia... .1069
MH 02263-01 NPB HaloperidolZOl Pharmacodynamics and Clinical
Response in Schizophrenia 1073
ZOl MH 02264-01 NPB Post Mortem Brain Tissue Examination
in Psychiatric Disorders 1079
ZOl MH 02265-01 NPB Catecholamine Changes inBinding Site
Human Post Mortem Tissue 1083
ZOl MH 02266-01 NPB Quantitative Assessment of Motor Function
in Schizophrenia 1089
ZOl MH 02267-01 NPB Brain Electrical Activity Mapping in
Neuropsychiatric Patients 1093
ZOl MH 02268-01 NPB The Clinical Phenomenology of Multiple
Personality Disorder 1099
ZOl MH 02269-01 NPB The Development, Reliability and Validity
of a Dissociation Scale 1103
IIZOl MH 02270-01 NPB The Psychophysiology of Multiple
Personal ity 1105
ZOl MH 02271-01 NPB Fenfluramine and Chronic Schizophrenia. .1107
ZOl MH 02272-01 NPB Sodium Fluoride Treatment of Alzheimer's
Di sease (AD) 1111
ZOl MH 02273-01 NPB White House Cases: Predictors of
Future Vi ol ence 1115
ZOl MH 02274-01 NPB Exploration of New Methods for Treatment
of Intractable Epilepsy 1119
ZOl MH 02275-01 Search for inNPB Virus Post Mortem Brain
of Patients with Schizophrenia 1123
ZOl MH 02276-01 NPB Localization of Met5-Enkephalin-Arg6-
Phe^-Li Immunoreactike vity 1 1 29
ZOl MH 02277-01 NPB Regional Cerebral Blood Flow in
Neuropsychiatric Patients and in
Normal Subjects 1 1 31
ZOl MH 02278-01 NPB Structural Brain Imaging in Schizophrenic
Patients and Normal Subjects 1137
ZOl MH 02279-01 NPB Comparison of Neuroleptic Induced
Supersensitivity in Mice 1143
ZOl MH 02280-01 NPB Brain Tissue Transplantation in
Primates 1145
ZOl MH 02281-01 NPB Neural Tissue Microchip Interface 1151
ZOl MH 02282-01 NPB Neurovi rology and Neuroimmunology of
Schizophrenia 1153
LABORATORY OF PRECLINICAL PHARMACOLOGY
ZOl MH 01506-11 SMRP Narcotic Analgesics and the Regulation
of Catecholamine Neurons 1161
ZOl MH 01514-13 SMRP Trans-synaptic Control of Protein
Synthesi s 1163
ZOl MH 01516-12 SMRP Biochemical Pharmacology of Minor
Tranquil i zers 1165
IIIRole of Substance P and01521-10 SMRP FunctionalZOl MH
Other Peptides in Nervous System 1167
Regulation of Gene Expression and ProteinZOl MH 01525-09 SMRP
Synthesis of Neural Tissues 1169
Synthesis andMH 01531-08 SMRP Nerve Growth Factors:ZOl
1173Funct i on
Regulation of Catecholamine Receptor....! 177ZOl MH 01532-08 SMRP
Trans-synaptic Control of the Ca^+ZZOl MH 01537-07 SMRP
Protein Kinase. ..1181Phospholipid-Dependent
of Imipramine Binding SitesZOl MH 01549-06 SMRP Regulation
Brain 1185in Rat
Agonist and Antagonist of BenzodiazepineZOl MH 01552-05 SMRP
Receptors 1 1 91
of Enkephalins in BovineZOl MH 01553-05 SMRP Biosynthesis
Adrenal Medulla 1193
01555-05 SMRP Enkephalin Metabolism 1195ZOl MH
Immunohistochemical Studies on Neuro-ZOl MH 01558-04 SMRP
transmitters in the Nervous System 1197
Phe-Met-Arg-MH 01559-04 SMRP Met-Enkephal in-Arg-Phe andZOl
11 99Phe-NH2 in the Brain and Spinal Cord....
MH 01561-04 SMRP Neuropeptides and SomatosensoryZOl
Processing 1 201
Basic Proteins inZOl MH 01567-02 SMRP Role of Synaptosomal
Function...1205the Control of GABA Receptor
ZOl MH 01569-03 SMRP Interaction with Neuropeptides 1209
azepine Receptor Complex inZOl MH 01571-03 SMRP GABA/Benzodi
Adrenal Medul la 1211
ZOl MH 01572-03 SMRP Endogenous Effector for
1Benzodi azepi nes 21 3
Search Models to Study ReceptorsZOl MH 01573-03 SMRP A for
Emission ComputedIn Vivo by
Tomography 121 7
IVZOl MH 01574-03 SMRP Peptide Ligands for Nicotinic
Receptors 1 221
ZOl MH 01577-02 SMRP Characterization of Serotonin Pre- and
Postsynaptic Components in NCB-20
Cells 1223
Expression of Genes for Insulin in BrainZOl MH 01578-02 SMRP
and Peripheral Tissues 1227
ZOl MH 01579-02 SMRP Studies of an Endacoid for the 5HT2
Recogni ti on Site 1 229
01580-01 Role of Neuropeptides Derived fromZOl MH SMRP
Proopiomelanocortin 1233
ZOl MH 01583-02 SMRP Receptors for Excitatory Amino Acid
Neurotransmitters 1 235
ZOl MH 01584-02 SMRP Noncompetitive Interactions Between Mu-
and Delta-Opiate Receptors In Vitro 1237
Molecular Mechanisms of Smooth MuscleZOl MH 01585-01 SMRP
Cell Contraction in Rat Aorta 1241
ZOl MH 01586-01 SMRP Immunohistochemical Studies on DBI and
GABA in the Nervous System 1245
Dihydropyridi Block Calcium UptakeZOl MH 01587-01 SMRP nes
into Cerebellar Granule Cells 1249
ZOl MH 01588-01 SMRP GABA B Receptors Inhibit Adenylate
Cycl ase 1 251
ZOl MH 01589-01 SMRP Target-derived Neuronotrophic Factors .1 253..
ZOl MH 01590-01 SMRP Origin of FMRF-NH^ Immunoreactivity
in Rat Spinal Cord 1255
MH 01591-01 Abnormality of Alpha-adrenergic ReceptorsZOl SMRP
in the Frontal Cortex of GEPR 1259
ZOl MH 01592-01 SMRP Studies on an Anxiogenic Neuropeptide
(DBI) in Human Brain and
Cerebrospinal Fluid 1261
ZOl MH 01593-01 SMRP Excitatory Amino Acid Receptor Function
in Cerebellar Granule Cells 1265
ZOl MH 01594-01 SMRP Excitatory Amino Acid Receptors are
Coupled with Phosphoinositide
1 267Metabol i sm
V