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Candidate gene association testing in the dissection of genetic causes for depressive disorders and the response to antidepressant treatment [Elektronische Ressource] / Daria Salyakina

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129 Pages
English

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Published 01 January 2007
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Exrait

sc
durc
to
t
W
or
w
En
haften
V
Prüfer
F
of
Univ
w
W
and
Erlangung
W
eines
treatmen
genehmigten
Candidate
Prof.
druc
Univ.

akultät
wurde
und
T
causes
eingereic
haftszen
akultät
e
Landn
Lehrstuhl
.2007
resp
ak
ersität
G
tidepressan
der
wic
rer.
Daria
V
für
U
llständiger
E.
asso
Dissertation:
der
Dr.
2.
r
Dr.
the
Die
haftszen
29.03.2007
Wissensc
ei
genetic
hnisc
Um
Münc
f
t
Univ
die
depressiv
haftszen
elt
für
disorders
und
trum
am
the
zur
für
des
onse
ademi
hnisc
hen
an
rades
t
Doktors
t
Naturwissensc
eihenstephan
(Dr.
t
nat.)
klungsgenetik
Dissertation.
Salyakina
orsi
Münc
zender:
o
niv.
gene
Dr.
Ab
Grill
Ernährung,
der
k
1.
ciation
Prof.
v
W.
urst
de
Univ.
in
Prof.
F
H.R.
utzung
ries
Wissensc
Dissertation
dissection
am
trum
b
der
ec
he
hen
Landn
testing
on
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eihenstephan
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für
hen
Ernährung,
ersität
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hen
utzung
h
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und
Um
h
w
F
elt
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der
trum
T
eihenstephan
ec
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hnisc
utzung
hen
Um
Univ
elt
ersität
31.08
Münc
angenommen.
hen
TRein,
b
time
tsc
ohli
times.
k
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Seaman
their
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ng
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institute
advices,
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to
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hnical
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his
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ork
fruitful
discussions
to
thanks
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for
helpful
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Psyc
for
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to
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all:
freedom
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knoledgemen
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me
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e
thanks
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thank
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on
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h,
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m
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advises.
de
e
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Damast,
o
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y
for
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w
our
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ideas,
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ts
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start
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to
out
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st
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for
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osition
stics,
the
science,
and
p
the
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t
etry
that
and
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cats.
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My
use
sincere
for
thanks
thesis
to
o
Martin
k
A.
i
K
Aaxis
.
.
.
asso
.
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.
.
6
.
.
.
rate
.
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.
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.
.
.
1.7.1
.
14
.
.
.
.
.
ncies
1.9.1
.
.
er
.
.
.
.
.
.
in
disorders
25
e
con
disequ
.
.
.
.
.
b
.
.
approac
opulation
.
.
.
.
i
.
concept
1.9
actors
.
.
a
.
.
.
.
.
erm
.
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e
metho
.
.
.
Ma
.
.
.
.
.
h
.
.
.
.
.
.
.
an
.
.
.
.
.
.
.
.
.
.
on
.
.
ectation-maximization
.
.
.
1.7.3
.
haplot
.
.
.
coalescen
.
.
.
.
1.8
.
.
.
.
1.4
.
mark
.
.
e
.
.
.
.
.
of
.
false
the
.
.
.
.
.
9
.
.
.
.
.
1.3.3
.
.
.
e
20
.
.
(eect
.
.
.
ciation
.
1.6
.
.
.
.
.
.
.
.
23
.
activit
.
tuitary
es
depression
.
.
Misclassication
an
13
.
4
.
ds
P
.
pharmacoki
.
drugs
.
.
.
.
librium
.
.
29
.
algorithm
.
.
.
.
.
.
structure
.
D
.
.
.
Hardy-W
.
.
The
equilibrium
algorithm
.
.
.
.
.
.
.
algorithm
.
for
1.3.6
es
.
.
.
.
.
1.7.4
.
Ba
.
.
.
.
.
.
.
.
.
.
in
1.3.2
.
.
.
.
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ase
.
c
.
1.3
.
.
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allele
testing
.
(MTP)
.
studies
.
.
.
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.
.

enitio
.
error
.
(FWER)
.
v
.
.
.
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.
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.
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o
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T
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.
.
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.
based
.
.
detect
.
.
.
enot
.
.
.
1.2
.
.
Com
e
.
.
.
asso
.
.
.
.
.
.
.
.
.
.
21
.
depression
yp
.
.
.
.
.
.
.
.
.
of
.
.
.
.
.
.
P
.
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othalamic
.
(HP
tro
ma
.
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6
.
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Pharmacogenetics
.
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.
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Haplot
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met
.
.
29
.
in
Link
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etics
age
pressan
.
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and
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.
.
i
.
.
.
.
.
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.
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14
.
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.
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.
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.
.
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duction
.
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.
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from
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ein
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exp
.
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(DHW)
.
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.
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.
of
.
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EM
.
based
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7
long
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yp
P
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stratication
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.
15
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.
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.
15
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Gene-gene
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teraction
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ery
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.
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In
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MTPs
5
.
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1
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.
G
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g
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yp
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1.9.3
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bined
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risk
.
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.
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.
size)
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.
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ciation
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.
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.
.
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jectiv
.
.
.
.
.
11
1.10
.
jor
Haplot
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.
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es
.
studies
.
.
.
.
.
.
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.
.
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.
.
.
.
.
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.
.
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.
1.10.1
.
olymorphisms
complex
genes
.
trolling
.
y
.
the
.
yp
.
pi-
.
adrenal
.
A)
ts
and
.
jor
.
.
.
.
.
.
.
.
1.3.4
.
.
.
.
1.11
.
and
errors
tidepressan
.
drugs
.
.
1.7
.
.
.
yp
.
.
.
estimation
.
.
.
ho
.
1.3.1
.
.
1.11.1
.
olymorphisms
.
genes
.
the
ten
1
1
thesis
.
.
.
.
esian
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n
.
of
.
tide-
.
t
.
.
.
.
.
.
.
.
.
.
.
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.
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.
.
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.
.
.
iii
.
Con.
.
.
.
.
.
Psyc
depressiv
.
.
.
.
.
trolling
.
.
.
.
.
.
.
.
.
.
.
.
4.2.1
yp
.
.
.
yping
erit
.
.
.
.
gene
t
.
.
.
58
.
Bi
.
.
3.2.2
D
.
H
.
.
.
.
.
.
.
.
.
.
.
.
erit
.
.
.
.
.
tidepressan
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ds
.
.
3.1.4
4.1.1
.
.
.
.
.
onse
.
.
c
.
.
.
.
.
.
and
o
.
and
.
.
.
.
.
.
.
.
.
2.2
.
.
.
43
.
.
.
.
.
.
assa
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.
sso
.
.
.
.
.
.
3.2.5
.
.
FKBP5
.
.
.
of
.
t
.
.
.
.
.
.
SNP
ariation
.
resp
.
t
.
Materials
.
.
.
.
.
.
.
.
analysis
.
.
.
.
.
40
.
.
.
.
and
.
pressan
a
.
.
.
.
.
.
Con
ciated
.
.
.
correction
.
.
.
3.1
v
.
i
in
.
3.2.1
.
.
.
trol
.
.
.
.
.
.

.
.
.
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o
.
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.
.
.
.
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.
.
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analysis
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esting
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description
c
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.
.
.
.
.
.
4.1.10
.
.
.
.
.
.
.
.
ot
.
.
.
.
.
.
.
.
37
.
.
.
preparation
.
genot
.
.
.
.
.
.
.
.
.
.
4.2.3
.
FKBP5
.
onse
.
.
.
.
.
65
.
.
.
.
.
.
44
.
.
4
and
genes
.
A
.
to
.
treat-
.
depression
.
54
.
Meth
.
.
.
.
ultiple
.
.
.
.
.
.
.
.
.
c
.
.
atien
.
.
.
.
.
.
.
.
.
.
.
.
.
.
P2RX7,
.
.
57
.
assessmen
.
of
ding
an
.
drug
.
.
3.2
.
ligand-gated
.
.
.
.
.
.
.
is
57
.
.
.
.
.
.
ma
.
.
.
pro
.
.
.
disorder
.
.
.
2.3
SNP
.
,
and
y
.
.
.
.
.
.
.
.
llele
58
estigation
.
y
.
.
.
.
.
.
.
.
.
.
.
.
.
.
4.1.6
.
sequencing
.
.
.
.
.
.
con
.
.
.
asso
4.1.7
.
and
.
.
.
.
.
.
2.1
.
.
.
.
.
.
62
.
yp
.
.
.
.
.
.
.
.
3.2.3
.
Sam
.
LD
.
.
4.1.9
.
analysis
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
orter
.
.
.
.
.
.
.
.
.
.
3.2.4
.
.
.
of
4.2
.
.
es
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
D
.
.
3.1.2
.
.
.
Discussion
.
orativ
.
.
.
e
.
.
.
correlation
4.2.2
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
sso
.
olymorphisms
.
depression
.
and
.
an
.
y
.
.
m
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
3.1.3
.
.
52
selection
V
.
in
genot
con
.
HP
.
axis
.
onse
.
an
.
t
.
men
.
and
.
sev
.
y
.
4.1
.
and
.
o
.
.
.
.
.
.
.
.
Nyholt's
.
.
.
.
.
.
.
.
.
.
.
.
.
44
.
.
.
Statisti
.
.
.
al
57
.
P
.
ts
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
3
.
.
.
.
.
.
.
a
.
.
4.1.2
testing
hopathological
.
t
co
denition
.
resp
.
to
.
tide-
for
t
.
treatmen
.
.
44
.
purinergic
.
Results
.
.
.
.
.
ion
.
.
.
.
.
.
.
hannel,
.
.
.
.
.
.
4.1.3
asso-
trols
.
.
.
.
.
.
with
.
.
.
.
.
.
.
jor
.
.
.
aluation
.
.
.
e
.
.
.
34
.
.
.
42
.
.
.
.
4.1.4
.
disco
Materials
ery
.
selection
Theoretical
genot
.
p
meth
ng
.
.
.
.
.
.
ds
.
46
.
v
.
A
.
.
.
frequencies
4.1.5
.
oinformatics
qualit
.
.
.
con
.
.
.
.
.
.
.
.
.
31
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
61
.
FKBP5
.
mRNA
.
.
.
.
.
.
.
.
46
.
.
.
Case
.
.
.
tr
.
.
.
l
.
.
61
ciation
L
33
-testing
.
tSNPs
.
.
.
.
.
.
.
.
.
.
.
.
cedure
.
.
.
.
.
.
.
.
.
.
.
.
.
.
4.1.8
Results
aplot
.
e
.
.
.
.
.
.
.
.
.
.
.
.
.
.
46
.
3.1.1
.
T
.
.
.
for
.
ple
.
.
.
.
62
.
Statisti
.
al
.
.
.
.
.
.
.
.
.
.
Metho
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
62
.
Rep
.
gene
.
ys
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
50
.
.
.
A
.
.
.
ciation
.
.
64
hapl
Results
.
.
yp
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
65
.
L
.
testing
43
.
.
.
2.4
.
.
.
DNA
.
51
.
.
.
Expl
.
.
.
e
.
.
.
yp
.
.
.
phenot
.
.
.
e
.
.
65
.
Sequencing
.
mRNA
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
Ev
of
for
ds
.
.
.
.
.
.
.
.
.
65
52
A
3.3
ciations
Discussion
p
.
in
.
with
.
sev
.
y
.
resp
.
to
.
tidepressan
.
therap
.
.
.
.
.
.
.
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