Candidate gene association testing in the dissection of genetic causes for depressive disorders and the response to antidepressant treatment [Elektronische Ressource] / Daria Salyakina

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• Published by: technische_universitat_munchen
• Published: 01 January 2007
• Reads: 17
• Language: English
• Document size: 2 MB

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durc
to
t
W
or
w
En
haften
V
Prüfer
F
of
Univ
w
W
and
Erlangung
W
eines
treatmen
genehmigten
Candidate
Prof.
druc
Univ.

akultät
wurde
und
T
causes
eingereic
haftszen
akultät
e
Landn
Lehrstuhl
.2007
resp
ak
ersität
G
tidepressan
der
wic
rer.
Daria
V
für
U
llständiger
E.
asso
Dissertation:
der
Dr.
2.
r
Dr.
the
Die
haftszen
29.03.2007
Wissensc
ei
genetic
hnisc
Um
Münc
f
t
Univ
die
depressiv
haftszen
elt
für
disorders
und
trum
am
the
zur
für
des
onse
ademi
hnisc
hen
an
rades
t
Doktors
t
Naturwissensc
eihenstephan
(Dr.
t
nat.)
klungsgenetik
Dissertation.
Salyakina
orsi
Münc
zender:
o
niv.
gene
Dr.
Ab
Grill
Ernährung,
der
k
1.
ciation
Prof.
v
W.
urst
de
Univ.
in
Prof.
F
H.R.
utzung
ries
Wissensc
Dissertation
dissection
am
trum
b
der
ec
he
hen
Landn
testing
on
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eihenstephan
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für
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Ernährung,
ersität
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hen
utzung
h
und
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Um
h
w
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elt
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der
trum
T
eihenstephan
ec
Ernährung,
hnisc
utzung
hen
Um
Univ
elt
ersität
31.08
Münc
angenommen.
hen
TRein,
b
time
tsc
ohli
times.
k
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Ste
Seaman
their
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ng
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with
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institute
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to
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hnical
Shaun
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y
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his
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njo
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me
ork
fruitful
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thanks
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Psyc
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thanks
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advises.
de
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Damast,
o
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y
for
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w
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ideas,
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ts
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to
out
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st
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for
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osition
stics,
the
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etry
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My
use
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thanks
thesis
to
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Martin
k
A.
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6
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rate
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.
14
.
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.
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.
ncies
1.9.1
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er
.
.
.
.
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.
in
disorders
25
e
con
disequ
.
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.
.
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b
.
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approac
opulation
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i
.
concept
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actors
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a
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erm
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e
metho
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Ma
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an
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on
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.
.
.
1.7.3
.
haplot
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coalescen
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.
.
1.8
.
.
.
.
1.4
.
mark
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e
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of
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false
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9
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1.3.3
.
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e
20
.
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.
ciation
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1.6
.
.
.
.
.
.
.
.
23
.
activit
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tuitary
es
depression
.
.
Misclassication
an
13
.
4
.
ds
P
.
pharmacoki
.
drugs
.
.
.
.
librium
.
.
29
.
algorithm
.
.
.
.
.
.
structure
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.
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The
equilibrium
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algorithm
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es
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.
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in
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.
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ase
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(MTP)
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studies
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error
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v
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detect
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enot
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21
.
depression
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.
.
.
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.
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of
.
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ma
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Haplot
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met
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29
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in
Link
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and
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14
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P
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15
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5
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1.9.3
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risk
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size)
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jectiv
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11
1.10
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jor
Haplot
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es
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studies
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.
olymorphisms
complex
genes
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.
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.
pi-
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.
A)
ts
and
.
jor
.
.
.
.
.
.
.
.
1.3.4
.
.
.
.
1.11
.
and
errors
tidepressan
.
drugs
.
.
1.7
.
.
.
yp
.
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estimation
.
.
.
ho
.
1.3.1
.
.
1.11.1
.
olymorphisms
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genes
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the
ten
1
1
thesis
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esian
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.
of
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.
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iii
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depressiv
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trolling
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.
.
.
4.2.1
yp
.
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yping
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gene
t
.
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.
58
.
Bi
.
.
3.2.2
D
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H
.
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.
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erit
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3.1.4
4.1.1
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onse
.
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c
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and
o
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2.2
.
.
.
43
.
.
.
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assa
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sso
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3.2.5
.
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FKBP5
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of
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SNP
ariation
.
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.
Materials
.
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analysis
.
.
.
.
.
40
.
.
.
.
and
.
pressan
a
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.
.
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Con
ciated
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correction
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.
.
3.1
v
.
i
in
.
3.2.1
.
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trol
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.
.

.
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o
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analysis
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esting
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description
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ot
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.
37
.
.
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preparation
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genot
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.
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onse
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65
.
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.
.
44
.
.
4
and
genes
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A
.
to
.
treat-
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depression
.
54
.
Meth
.
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.
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ultiple
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.
.
.
.
.
.
.
.
c
.
.
atien
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.
P2RX7,
.
.
57
.
assessmen
.
of
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an
.
drug
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.
3.2
.
ligand-gated
.
.
.
.
.
.
.
is
57
.
.
.
.
.
.
ma
.
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pro
.
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.
disorder
.
.
.
2.3
SNP
.
,
and
y
.
.
.
.
.
.
.
.
llele
58
estigation
.
y
.
.
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.
.
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.
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.
.
4.1.6
.
sequencing
.
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.
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con
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.
.
asso
4.1.7
.
and
.
.
.
.
.
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2.1
.
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.
.
62
.
yp
.
.
.
.
.
.
.
.
3.2.3
.
Sam
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LD
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4.1.9
.
analysis
.
.
.
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.
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orter
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3.2.4
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.
of
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es
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D
.
.
3.1.2
.
.
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Discussion
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orativ
.
.
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e
.
.
.
correlation
4.2.2
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
sso
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olymorphisms
.
depression
.
and
.
an
.
y
.
.
m
.
.
.
.
.
.
.
.
.
.
.
.
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.
.
3.1.3
.
.
52
selection
V
.
in
genot
con
.
HP
.
axis
.
onse
.
an
.
t
.
men
.
and
.
sev
.
y
.
4.1
.
and
.
o
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Nyholt's
.
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44
.
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.
Statisti
.
.
.
al
57
.
P
.
ts
.
.
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.
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.
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3
.
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a
.
.
4.1.2
testing
hopathological
.
t
co
denition
.
resp
.
to
.
tide-
for
t
.
treatmen
.
.
44
.
purinergic
.
Results
.
.
.
.
.
ion
.
.
.
.
.
.
.
hannel,
.
.
.
.
.
.
4.1.3
asso-
trols
.
.
.
.
.
.
with
.
.
.
.
.
.
.
jor
.
.
.
aluation
.
.
.
e
.
.
.
34
.
.
.
42
.
.
.
.
4.1.4
.
disco
Materials
ery
.
selection
Theoretical
genot
.
p
meth
ng
.
.
.
.
.
.
ds
.
46
.
v
.
A
.
.
.
frequencies
4.1.5
.
oinformatics
qualit
.
.
.
con
.
.
.
.
.
.
.
.
.
31
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
61
.
FKBP5
.
mRNA
.
.
.
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.
.
.
.
46
.
.
.
Case
.
.
.
tr
.
.
.
l
.
.
61
ciation
L
33
-testing
.
tSNPs
.
.
.
.
.
.
.
.
.
.
.
.
cedure
.
.
.
.
.
.
.
.
.
.
.
.
.
.
4.1.8
Results
aplot
.
e
.
.
.
.
.
.
.
.
.
.
.
.
.
.
46
.
3.1.1
.
T
.
.
.
for
.
ple
.
.
.
.
62
.
Statisti
.
al
.
.
.
.
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.
.
.
Metho
.
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.
.
.
62
.
Rep
.
gene
.
ys
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
50
.
.
.
A
.
.
.
ciation
.
.
64
hapl
Results
.
.
yp
.
.
.
.
.
.
.
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.
65
.
L
.
testing
43
.
.
.
2.4
.
.
.
DNA
.
51
.
.
.
Expl
.
.
.
e
.
.
.
yp
.
.
.
phenot
.
.
.
e
.
.
65
.
Sequencing
.
mRNA
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
Ev
of
for
ds
.
.
.
.
.
.
.
.
.
65
52
A
3.3
ciations
Discussion
p
.
in
.
with
.
sev
.
y
.
resp
.
to
.
tidepressan
.
therap
.
.
.
.
.
.
.
.
.
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