Characterization of bacteria, antibiotics of the fluoroquinolone type and their biological targets DNA and gyrase utilizing the unique potential of vibrational spectroscopy [Elektronische Ressource] / von Ute Neugebauer
265 Pages
English

Characterization of bacteria, antibiotics of the fluoroquinolone type and their biological targets DNA and gyrase utilizing the unique potential of vibrational spectroscopy [Elektronische Ressource] / von Ute Neugebauer

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Characterization of bacteria,antibiotics of the fluoroquinolone typeand their biological targets DNA and gyraseutilizing the unique potential of vibrationalspectroscopyDissertationzur Erlangung des akademischen Grades doctor rerum naturalium(Dr. rer. nat.)vorgelegt dem Rat der Chemisch Geowissenschaftlichen Fakultät derFriedrich Schiller Universität Jenavon Dipl. Chemikerin Ute Neugebauergeboren am 23. November 1978 in ErfurtGutachter:1. Prof. Dr.2. Prof. Dr.Tag der öffentlichen Verteidigung:Contents1 Introduction 12 Theoretical fundamentals 72.1 Vibrational Spectroscopy . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 72.2 Atomic force microscopy (AFM) . . . . . . . . . . . . . . . . . . . . . . . . . . 222.3 Statistical evaluation methods: Multivariate data analysis . . . . . . . . . . . . . 243 Material and Methods 293.1 Spectroscopic instrumentation . . . . . . . . . . . . . . . . . . . . . . . . . . . 293.2 Biological samples . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 383.3 Data treatment . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 463.4 Statistical data analysis . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 473.5 DFT calculation . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 504 Bacteria 534.1 Vibrational spectroscopic characterization . . . . . . . . . . . . . . . . . . . . . 544.2 V discrimination of bacteria . . . . . . . . . . . . . . .

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Published 01 January 2007
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Language English
Document size 18 MB