Characterization of estrogen receptor {α [alpha] in mouse osteoblasts [Elektronische Ressource] / presented by Dominique Manu

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Dissertation Submitted to the Combined Faculties for the Natural Sciences and for Mathematics Of the Ruperto-Carola University of Heidelberg, Germany For the degree of Doctor of Natural Sciences Presented by Diplom-Biologe Dominique Manu Born in Toulouse Oral examination: Characterization of Estrogen Receptor α in Mouse Osteoblasts Referees: Prof. Dr. Thomas Braunbeck Dr. Jürg Müller 2 3Table of contents TABLE OF CONTENTS .......................................................................................... 4 AKNOWLEDGEMENTS......................................................................................... 7 SUMMARY................................................................................................................ 8 INTRODUCTION..................................................................................................... 9 1. INTRODUCTION: A HISTORICAL OVERVIEW ...................................................... 10 2. STRUCTURAL AND FUNCTIONAL ASPECTS OF ER Α .......................................... 12 2.1. ER α functional domains........................................................................ 13 2.2. Interaction between N-and C- terminal domains and the basis of ligand dependent activity.............................................................................................. 18 3. ER Α MEDIATED TRANSCRIPTION .....................................

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Published 01 January 2004
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Language English
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