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Characterization of neuropeptide Y-mediated behavioral effects in F344 rat substrains with a differential dipeptidyl-peptidase IV (DPPIV; CD 26) enzymatic activity [Elektronische Ressource] / von Tim Karl

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Characterization of neuropeptide Y-mediated behavioral effects in F344 rat substrains with a differential dipeptidyl-peptidase IV (DPPIV; CD26) enzymatic activity Von dem Fachbereich Biologie der Universität Hannover zur Erlangung des Grades eines DOKTORS DER NATURWISSENSCHAFTEN Dr. rer. nat. genehmigte Dissertation von Tim Karl geboren am 20.09.1973 in Kirchhellen 2003 Referent: Prof. Dr. H.J. Hedrich Korreferent: Prof. Dr. S. Steinlechner Tag der Promotion: 27.11.2003 Abstract The ectopeptidase dipeptidyl-peptidase IV (DPPIV; CD26) specifically truncates dipeptides from substrates with an alanine or proline at the second N-terminal position of the amino acid sequence. Due to this specificity, the neurotransmitter neuropeptide Y (NPY) represents one of the best substrates for DPPIV but implications of the “DPPIV-NPY” interactions on behavioral responses in vivo have not been investigated. The aims of the present studies were (1) to characterize the phenotype of two mutant F344 rat substrains [F344/DuCrj(DPPIV-) and F344/Crl(Ger/DPPIV-) ], which exhibit an extreme reduction of their endogenous DDPIV activity, and of a wildtype-like F344 substrain [F344/Crl(Por)], and (2) to test the hypothesis whether this lack of enzymatic activity is associated with differential in vivo effects of centrally applied NPY.

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Published 01 January 2003
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Language English
Document size 1 MB