Combined assessment of drug dissolution and epithelial permeability [Elektronische Ressource] : implementation of online TEER measurement and extension to BCS class III and IV compounds / von Marco Mündörfer
111 Pages
English

Combined assessment of drug dissolution and epithelial permeability [Elektronische Ressource] : implementation of online TEER measurement and extension to BCS class III and IV compounds / von Marco Mündörfer

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Combined assessment of drug dissolution and epithelial permeability: Implementation of online TEER measurement and extension to BCS class III and IV compounds Dissertation zur Erlangung des Grades des Doktors der Naturwissenschaften der Naturwissenschaftlich-Technischen Fakultät III Chemie, Pharmazie, Bio- und Werkstoffwissenschaften der Universität des Saarlandes von Marco Mündörfer Saarbrücken 2010 Tag des Kolloquiums: 16.12.2010 Dekan: Prof. Dr. Stefan Diebels Berichterstatter: Prof. Dr. Claus-Michael Lehr Prof. Dr. Udo Bakowsky Vorsitz: Prof. Dr. Gregor Jung Akad. Mitarbeiter: Dr. Ulrich F. Schäfer Die vorliegende Arbeit entstand auf Anregung und unter der Anleitung von Herrn Prof. Dr. Claus-Michael Lehr in Zusammenarbeit mit der Sanofi-Aventis Deutschland GmbH am Lehrstuhl für Biopharmazie und Pharmazeutische Technologie der Universität des Saarlandes. Abstract Abstract Measurement of drug dissolution and permeation of solid oral dosage forms in a combined experiment is a quite obvious research approach that nevertheless has only been sparsely considered up to now. In the present work an existing apparatus that has been developed for the mentioned purpose has been adapted to comply with the requirements for the analy-sis of low permeable compounds of BCS classes III and IV.

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Published 01 January 2010
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Language English
Document size 1 MB