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Determination of uPA and PAI-1 by ELISA in small amounts of breast cancer tissue [Elektronische Ressource] : clinical evaluation in pre- and post-primary systemic therapy specimens / Sven Frederik Lienert

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106 Pages
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Frauenklinik und Poliklinik Klinikum rechts der Isar der Technischen Universität München Determination of uPA and PAI-1 by ELISA in Small Amounts of Breast Cancer Tissue: Clinical Evaluation in Pre- and Post-Primary Systemic Therapy Specimens Sven Frederik Lienert Vollständiger Abdruck der von der Fakultät für Medizin der Technischen Universität München zur Erlangung des akademischen Grades eines Doktors der Medizin genehmigten Dissertation. Vorsitzender: Univ.-Prof. Dr. D. Neumeier Prüfer der Dissertation: 1. apl. Prof. Dr. N. Harbeck 2. Univ.-Prof. Dr. M. Schmitt Die Dissertation wurde am 25.10.2007 bei der Technischen Universität München eingereicht und durch die Fakultät für Medizin am 09.04.2008 angenommen. Sven F. Lienert Determination of uPA and PAI-1 by ELISA in Small Amounts of Breast Cancer Tissue: Clinical Evaluation in Pre- and Post-Primary Systemic Therapy Specimens Table of contents Table of contents I Abbreviation Index II 1 Summary 1 2 Introduction 2 2.1 Breast Cancer Epidemiology 3 2.2 Breast Cancer as Systemic Disease 3 2.3 Tumor Invasion and Metastasis 4 2.4 Level of Evidence (LOE) Classification and Clinical Utility of uPA and PAI-1 6 2.5 Preclinical Relevance of the Urokinase-Plasminogen-Activation System 8 2.6 Clinical Relevance of the Urokinase-Plasminogen-Activation System 9 2.7 Measurement of uPA and PAI-1 15 2.8 Tissue Sampling 18 2.

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Published 01 January 2008
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