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Evolutionary bioinformatics [Elektronische Ressource] : predicting genetic stability of asexual genomes by global computing / Laurence Loewe

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Published 01 January 2003
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Language English
Document size 11 MB

















































































There are problems in evolutionary biology that can
only be solved by massive computing power. Howev-
er, extensive use of computers creates problems of its
own, usually new to biologists. This thesis contains
the journey of a biologist, who was not content with
the computing limitations of his day. He set out to
create the first globally distributed computing sys-
tem for evolutionary biology on the Internet:
evolution@home.
Its first public simulator addresses Muller’s ratchet,
a population genetic process that might cause ex-
tinctions of asexual genetic systems like mitochon-
dria, non-recombining bacteria and others. This
could not only contribute to extinctions of species,
but also to the uncultivable majority of microbes.
You are invited to join the quest of
how organisms manage to stay alive.
A copy of this dissertation can be downloaded from
http://www.evolutionary-research.net/
© Laurence Loewe 2003





































































Fachgebiet Mikrobielle Ökologie
Department für Biowissenschaftliche Grundlagen
Technische Universität München
EVOLUTIONARY BIOINFORMATICS:
PREDICTING GENETIC STABILITY
OF ASEXUAL GENOMES BY
GLOBAL COMPUTING
Laurence Loewe
Vollständiger Abdruck der von der Fakultät Wissenschaftszentrum Weihenstephan für Ernährung,
Landnutzung und Umwelt der Technischen Universität München zur Erlangung des akademischen
Grades eines
Doktors der Naturwissenschaften (Dr. rer. nat.)
genehmigten Dissertation.
Vorsitzender: Univ.-Prof. Dr. rer. nat. Ludwig Trepl
Prüfer der Dissertation: 1.Siegfried Scherer,
2.Eberhard Bertsch, Ruhr-Universität Bochum

Die Dissertation wurde am 12. November 2002 bei der Technischen Universität München
eingereicht und durch die Fakultät Wissenschaftszentrum Weihenstephan für Ernährung,
Landnutzung und Umwelt am 9. Dezember 2002 angenommen.
Laurence Loewe (2002) Diss, TU-München Printed at 16 Apr 2003