Functional characterization of Lupli, a new component of the oskar RNP complex in the Drosophila oocyte [Elektronische Ressource] / presented by Lukas Neidhart

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Functional characterization of Lupli, a newcomponent of the oskar RNP complex inthe Drosophila oocyteLukas NeidhartSeptember 2007 Dissertation submitted to the Combined Faculties for the Natural Sciences and for Mathematics of the Ruperto-Carola University of Heidelberg, Germany for the degree of Doctor of Natural Sciences presented by Lukas Neidhart (Diploma in Biology) Born in Boston (MA), USA Oral Examination: October 26, 2007 Functional characterization of Lupli, a new component of the oskar RNP complex in the Drosophila oocyte Referees: Dr. Darren Gilmour Prof. Dr. G. Elisabeth Pollerberg Contents1 Introduction 111.1 RNA localization . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 111.1.1 Different functions in different systems . . . . . . . . . . . . . . . . . . . . . 111.1.2 Mechanisms . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 131.2 Drosophila oogenesis . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 151.3 Axis determination in Drosophila . . . . . . . . . . . . . . . . . . . . . . . . . . . . 161.3.1 Establishment of the antero-posterior axis by gurken . . . . . . . . . . . . . 191.3.2 Determination of the dorsal-ventral axis by gurken . . . . . . . . . . . . . . 201.3.3 Determination of the anterior-posterior axis by bicoid . . . . . . . . . . . . 211.3.4 Biological role of Oskar . . . . . . . . . . . . . . . . . . . . . .

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Published 01 January 2007
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