Gene expression noise and robustness in the Escherichia coli chemotaxis pathway [Elektronische Ressource] = Rauschen der Genexpression und Robustheit im Escherichia coli Chemotaxis Signalweg / Linda Elisabeth Lv̨dok

-

English
159 Pages
Read an excerpt
Gain access to the library to view online
Learn more

Description

Gene expression noise and robustness inthe Escherichia coli chemotaxis pathwayDissertation submitted to theCombined Faculties for the Natural Sciences and forMathematicsof the Ruperto-Carola University of Heidelberg, Germanyfor the degree ofDoctor of Natural SciencesMSc. Linda Elisabeth Løvdokborn in: Drammen, NorwayDecember 2008From the group ofVictor Sourjikat theZMBHFirst referee: Prof. Dr. Bernd BukauSecond referee: Dr. Victor SourjikOral-examination: February 2009Some of the results presented in this work were reported in published papers orduring scientific meetings:PublicationsMarkus Kollmann, Linda Løvdok, Kilian Bartholome, Jens Timmer, VictorSourjik“Design principles of a bacterial signalling network”Nature, 438 (2005) 504-507Linda Løvdok, Markus Kollmann, Victor Sourjik“Co-expression of signaling proteins improves robustness of the bacterialchemotaxis pathway”Journal of Biotechnology 129 (2007) 173-180N. Vladimirov, L. Løvdok, D. Lebiedz, V. Sourjik“Rapid Cell: a tool to investigate dependence of bacterial chemotaxis onattractant gradients and adaptation time”PLoS Comput Biol., in pressL. Løvdok, N. Vladimirov, A. Müller, K. Bentele, D. Lebiedz, M. Kollmann,V. Sourjik“Role of translational coupling in robustness of bacterial chemotaxispathway”submittedOral Presentations (presenting author underlined)L. Løvdok, D. Kentner, S. Thiem, V. Sourjik“Signaling and robustness in the E.

Subjects

Informations

Published by
Published 01 January 2009
Reads 40
Language English
Document size 4 MB
Report a problem

Gene expression noise and robustness in
the Escherichia coli chemotaxis pathway
Dissertation submitted to the
Combined Faculties for the Natural Sciences and for
Mathematics
of the Ruperto-Carola University of Heidelberg, Germany
for the degree of
Doctor of Natural Sciences
MSc. Linda Elisabeth Løvdok
born in: Drammen, Norway
December 2008From the group of
Victor Sourjik
at the
ZMBH
First referee: Prof. Dr. Bernd Bukau
Second referee: Dr. Victor Sourjik
Oral-examination: February 2009Some of the results presented in this work were reported in published papers or
during scientific meetings:
Publications
Markus Kollmann, Linda Løvdok, Kilian Bartholome, Jens Timmer, Victor
Sourjik
“Design principles of a bacterial signalling network”
Nature, 438 (2005) 504-507
Linda Løvdok, Markus Kollmann, Victor Sourjik
“Co-expression of signaling proteins improves robustness of the bacterial
chemotaxis pathway”
Journal of Biotechnology 129 (2007) 173-180
N. Vladimirov, L. Løvdok, D. Lebiedz, V. Sourjik
“Rapid Cell: a tool to investigate dependence of bacterial chemotaxis on
attractant gradients and adaptation time”
PLoS Comput Biol., in press
L. Løvdok, N. Vladimirov, A. Müller, K. Bentele, D. Lebiedz, M. Kollmann,
V. Sourjik
“Role of translational coupling in robustness of bacterial chemotaxis
pathway”
submitted
Oral Presentations (presenting author underlined)
L. Løvdok, D. Kentner, S. Thiem, V. Sourjik
“Signaling and robustness in the E. coli chemotaxis pathway”
BLAST IX Meeting
2007.01.14– 19., Laughlin, Nevada, USA
Poster Presentations
L. Løvdok, M. Kollmann, V.Sourjik
“Gene expression noise in the E. coli chemotaxis pathway”
International Summer School on Molecular Imaging
2006.09.04– 08, Heidelberg, Germany
L. Løvdok, M. Kollmann, V.Sourjik“Gene expression noise in the E. coli chemotaxis pathway”
BLAST IX Meeting
2007.01.14– 19, Laughlin, Nevada, USA
L. Løvdok, M. Kollmann, V.Sourjik
“Gene expression noise and robustness in the E. coli chemotaxis pathway”
nd2 FEBS Advanced lecture course on Systems Biology from Molecules to
Life
2007.03.10– 16, Gosau, Austria
L. Løvdok, N. Vladimirov, K. Bentele, M. Kollmann, V.Sourjik
“Gene expression noise in the E. coli chemotaxis pathway”
Sensory Transduction in Microorganisms
2008.01.13– 18, Ventura, LA, USAGene expression noise and robustness in
the Escherichia coli chemotaxis pathway
Dissertation
by
MSc. Linda Elisabeth LøvdokAcknowledgements
First and foremost I must express my thanks to Prof. Dr. Bernd Bukau for
kindly supervising this thesis.
Also, my warmest gratitude goes to Dr. Victor Sourjik for his guidance, men-
toring and support during the past five years.
This work could not have been written without the fruitful collaboration with
Dr. Markus Kollmann and Kajetan Bentele at the Institute for Theoretical
Biology, Humboldt University Berlin, and Nikita Vladimirov at the Interdisci-
plinary Center for Scientific Computing, University of Heidelberg. Thanks to
Julia Rausenberger at the University of Freiburg for the helpful discussions.
For help with cloning, the microscope, computer problems, data analysis and
creating a wonderful working environment, cakes and shashlik, I would like
to thank all the former and present colleagues in the lab; Anette Müller,
Louisa Liberman, Sebastian Thiem, David Kentner, Gabriele Schwarz, Sonja
Schulmeister, Silke Neumann, Hui Li, Olga Oleksiuk, Maren Emmerich, Su-
sanneWölfelschneider, ErikSommer, MohitKumar, TanjaErhard, YilingYang,
Gabriele Malengo, Vladimir Jakovljevic, Barbara di Ventura, Francesca Chio-
varo and Stefan Viel.
Special thanks go to Marianne Uteng, Katharina Paulsen , Aksana Labokha,
Steffen Preissler and the bikers Jakob Tschäpe, Marco Pfeifer, Tomas Grübl and
Florentine Wahl for help with flat tires, for their patience uphill and the fun
outside of the lab.
Og så vil jeg takke jentene hjemme som ikke har glemt meg selv om jeg har
vært borte så lenge.
Jeg vil takke min søster, Nina, og mine fantastiske foreldre for at de alltid
har vært der for meg med oppmuntringer og støtte, og for at de har vært så
tålmodige og forståelsesfulle gjennom mine lange studier.
Zum Schluss möchte ich mich bei meinem Liebsten, Mark, ganz herzlich be-
danken. Ohne deine Unterstützung wäre ich ganz verloren. Ich habe so ein
Glück gehabt, dass ich dich kennengelernt habe. Danke, dass du immer für
mich da bist.