Long-term effects of chronic unpredictable mild stress on cell adhesion molecules NCAM and L1 in the regulation of behaviour in C57BL-6J mice [Elektronische Ressource] / vorgelegt von Ian Belle Stein
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Long-term effects of chronic unpredictable mild stress on cell adhesion molecules NCAM and L1 in the regulation of behaviour in C57BL-6J mice [Elektronische Ressource] / vorgelegt von Ian Belle Stein

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90 Pages
English

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Published 01 January 2009
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  ABAA CDE FBA EE AEAE  AE CDE E EBB E  BEBAABB E!""EC #BEAEB$ %E &EC' #E' BAA ((E  
 
 
)AE CC(A C (EB( "EB(A B AE  ( B ( *  )+ B A EAB C BE B *,-F)./0 B(
 
  1E !E  2E B #AE E B1B E B1BB( %AA E BEBAA E EA   
 
  F AB  #A *BA  E 3445  
 
           E B1BB( %AA E BEBAA E
 $ 46'+3'34+4 7E8CCAB(A BA 2B E B1BB( %AA E BEBAA E
&EDC(9 B 7EBA1$ &EC' #E' ' ((E &EDC($ 3' 2A(AE$ &EC' #E' #' : &EDC($ 6' 2A(AE$ &EC' #E' ' !      
 
3
 ;F)! <% *<;!;
BCDEFDE
 
 DECBECD'''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''
+'+ * B ( '''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''-
+'3 AE(AE  C(AB "E"EAB C  * '''''''''''''''''''''''''''''''''''''''''''''=
+'3'+ * ''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''=
+'3'+'+ &A" C *. B(''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''++
+'3'3 )+ ''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''+3
+'3'3'+ &A" C )+ CB(BA B( '''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''+6
+'6 * (A B( > ABE ((AB A E"(BAEB( BEE '''''''''+6
+'6'+ *. B( ''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''+6
+'6'3 )+. B( ''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''+?
+'? *EB( AE'''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''+,
+'?'+ AE ''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''+,
+'?'3 &BB( E" A (EB( AE ''''''''''''''''''''''''''''''''''''''''''''''''+/
+'?'6 *EB( AEEA "(BAEB( BEE B  '''''''''''''''''''''''''''+=
+'?'? AEAB B A @"EB C ( B ( *  )+ B
 
"(BAEB( BEE ''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''+5
  D FFFDE FD C EF E 
 
 EF D FEC !
6'+ B  E ''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''3?
6'3 *EB( "EB(A B AE A*B "EA( ''''''''''''''''''''''''''''''''''''3,
6'3'+ (B AE A"EAE  BAEB AEEB ''''''''''''''''''''''''''''''''''''''3/
6'3'3 !BEA AEE'''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''3=
6'6 FBE ''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''3=
6'6'+ %E (B( "CB C '''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''3=
6'6'3 !A " 1''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''35
6'6'6 %E( DBB AA A( DAEB'''''''''''''''''''''''''''''''''''''''''''''''''''''''''''64
6'6'? ;B "B AA '''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''6+
6'? *(AB C E  AB '''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''6+
6', +3,EBB AEB CE A FABAAB B C (EAB(AE
B A "''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''6+
 
6
 ;F)! <% *<;!;
6'/ E BAB '''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''63
6'- !ABAB C E  # (AA  "EBA C A " ''''''''''''''''''66
6'= EE ;E(EB"AB AE;B'''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''66
6'5 EAB EE AE(EB"AB "E (B E(AB AE;&*EB ''''''''6?
6'+4 AABAB(  '''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''6/
 
" FE #
?'+ &EG(A +$ EAAE CC(A C (EB( "EB(A B AE '''''''''''''''6-
?'+'+ !CC(A C (EB( "EB(A B AE  "EBB BE B
*,-F)./0 A  B( B A CE( DBB AA''''''''''''''''''''''''''''''''6-
?'+'3 EAAE CC(A C (EB( "EB(A B AE  @BA B B( B
A A" 1 AA''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''6=
?'+'6 EAAE CC(A C (EB( "EB(A B AE  "EBB
BE B B( B A AB "B AA ''''''''''''''''''''''''''''''''''''''''''''''''?4
?'+'? EAAE CC(A C (EB( "EB(A B AE   DBA B
*,-F)./0 A  B( '''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''?+
?'+'?'+ F DBA EB BAB '''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''?+
?'+'?'3 F DBA EB (EB( "EB(A B AE '''''''''''''''''''''''''''?3
?'+'?'6 F DBA 3  CAE (EB( "EB(A B AE ''''''''''''''''''?3
?'+', EAAE CC(A C (EB( "EB(A B AE  DBA C E
B *,-F)./0 A  B(''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''?6
?'+'/ EAAE CC(A C (EB( "EB(A B AE  A "
(EAB(AE ((AEAB B *,-F)./0 A  B(?,
?'+'- EAAE CC(A C (EB( "EB(A B AE  E
 
@"EB C ( B ( *9 )+  (EAB(AEB E("AE
E  2E B A B""(" C *,-F)./0 A  B( ''''''''''''''''''''?-
?'3 &EG(A 3$ )AE CC(A C (EB( "EB(A B AE'''''''''''''''',4
?'3'+ !CC(A C (EB( "EB(A B AE  "EBB BE B
*,-F)./0 A  B( B A CE( DBB AA ''''''''''''''''''''''''''''''',4
?'3'3 )AE CC(A C (EB( "EB(A B AE  @BA B B( B
A A" 1 AA'''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''',+
?'3'6 )AE CC(A C (EB( "EB(A B AE  "EBB
BE B B( B A AB "B AA '''''''''''''''''''''''''''''''''''''''''''''''',6
 
?
 
 ;F)! <% *<;!;
?'3'? )AE CC(A C (EB( "EB(A B AE   DBA B
*,-F)./0 A  B( ''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''',?
?'3'?'+ F DBA EB BAB ''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''',?
?'3'?'3 F DBA EB (EB( "EB(A B AE ''''''''''''''''''''''''''',?
?'3'?'6 F DBA +?  CAE AEBAB C (EB( "EB(A B
AE ''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''',?
?'3', )AE CC(A C (EB( "EB(A B AE  DBA C E
B *,-F)./0  B( '''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''',/
?'3','+ &E"AB  '''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''',/
?'3','3 E  '''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''',/
?'3','6 ;A''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''',/
?'3','? " '''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''',/
?'3'/ )AE CC(A C (EB( "EB(A B AE  A "
(EAB(AE ((AEAB B *,-F)./0 A  B( '''''''''''''''''''''''''',-
?'3'- )AE CC(A C (EB( "EB(A B AE  E
 
@"EB C A ( B ( *  )+  (EAB(AEB
E("AE E  2E B A B""(" C *,-F)./0 A  B(''''',5
" BCD $
,'+ *EB( "EB(A B AE B( "EBB BE B
*,-F)./0 A  B( '''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''/+
,'3 "BEA C A "AB("BABAEE @B CAE (EB(
"EB(A B AE''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''/6
,'6 E BE CAE +?  C AEBAB C (EB( "EB(A B
AE '''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''/,
,'? )AE DEAB C E @"EB C A E ( B
( A*B  BE(EAB(B E("AE AEB B A B""(" C
*,-F)./0 A  B( '''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''//
" $%
" FFFDBF
" B&DC'FFFDE(D&D)*
 FD )$
5'+ EBAB ''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''=/
 
,
 ;F)! <% *<;!;
5'3 *EEB( BA
''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''=5 
5'6 !BAAAB( 7EB(E ''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''
 
/
54
  ;E<#*;<
 DECBECD
  B++ ,- .+/0+  * B ( "  "BA E B A EBAB C BBB ( BA C(AB AB "EBB ((  (AEB@ BAE(AB'  A E A ( B ( E B"EAA CE EB( "A9 EAB E "EBCEAB9 BEAB9 EB9 EBA AEDA  @ B('  A "B  A EB9 ( B ( BBABA  EB " CEAB  "AB( "AB(BA A  ((E9 344-B' AEAB B A "E(  A E  "A B  D  AEEA  BEE AB  FB19 344-B'
* B ( E BB BA AE GE CBB$ A BAEB9 A (EB  A BB AB "ECB' E C BB "ECB (AB A A   B B DB( "EB "(BCB( BAE(AB DBA BB "EAE B  ((B B"A E' ; BB "ECB B CEAE BB ((EB A A "E( C AE C(AB B B CBE(AB A"  E"A AEBB BABCB  ABC B A @AE(E AEB@B ( CBE(AB9 A:EBAA A '9 +5=,B9 (AAB( B9  A" C AA(A A A ( E AFEDEC  EAG9 +55/H %B'+B' B "ECB E CA E @AB "AAEAB BCB(AB B ""EAB9 "BAAB  (AB'
 
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  ;E<#*;<
 10  C BCCEA E" C A BB AB "ECB E"EAAB C ( B (' E C A  "ECB (BA C  @AE(E B (ABB  B B' ; EA C A (  B( BCCEA B B CBE(AB A"  A%B E"A 9 CE AEE (9 AEE  BAE(E B' * AE ( B (B' #** AA B (E(A ((EB' 2 AB (BA ("EABB' %2%E ACBEA EDA C(AE E("AEB'  ABBB' 2& A(""ABBBAB' %6 A(A(ABB'   
 0/0 , 20/+ 33 2 1 B  
 DB  
; ( B ( * B BFBA @"E  (  C  E  "ABAAB( E9  (D (9 BE(A9 AE(A  ( ( AE  I9 +5=/H E A '9 +5==H BBE  ((E9 +5==B' * @BA B AE GE E BCE DB( E "E(  AEAB "B(B' ; AE GE E
 
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  ;E<#*;<
BCE E  CAE ABE ""E@BA (E DBA$ *+349 *+?4  *+=4' ; @AE(E "EA C  * BCE (BA C CB   AD % A"  ' ;EE BCE A* +=4  +?4 #B9 (AB BAB AEE  BAE(E B DE * +34 B (E A A E B (""ABBBA A"E A '9 +5=/H %B' 3B'  B"EAA B"(A  C(AB "E"EAB C * B BA BCB(AB' < A" C * BCB(AB B A AA(A C  3'= "BB( "E A A CBCA B B' ;B "E( B ((B "A  B EA  AD BCCEA 19 BA ;=B.;J  ;=B7.&; A< A '9 +55=B' F AAAB ( ( (A(A9 A "BA CE C &* EB @"E B A EB EB @BBAB  "EA ("(BA CE AE(AE  "AB( "AB(BA9 B(B A C(AE 9 A B""("  A "BABAE  AFCAB A '9 +553H 2B A '9 344+B'  ( A" C * BCB(AB B A AEAB "B( @ A7!B DB( B  +4 B (B F( B BEA BA A CEA B B' ; 7! BEA   C B E GE BCE C *A  9 +554B' A "E( (EEA DBA  (E ("(BA C * A "EA EBA AEDA DBAA9 DE9 CC(AB B "E"EAB A)EA1 A '9 +55-B' A A BB C E "A9
  A 6K C A * AE(EB"A (AB AB @' IBA AE "A "EE BA( C C(B(AB  ABBAB C "AB( (A(A E C E B"EA(9 DB( (EEA DBA  B(E C A A C 7! AE(EB"A B(E " A ,4K A A '9 +5==B' * B B B E "E( B B AE(AB9 ( "EBCEAB9 E ( BEAB9 EBA AEDA9 @ C(B(AB9 "AB( EB  EEAB AFEE%EE A '9 +553H #EA  I9 +553H 0LE9 +55,H "E A '9 +55,H %B
 A9 +55/HI  #EA +55/H *EE A '9 +55-H ((E9 +55-H BAE A '9 3443H   ((E 344-B'
 
5
  ;E<#*;<
%EAEE * EA EBA AB B BA BAE(AB DBA E&;&" AFEB A '9 344,B  * B B"EAA CE " CEAB  ABBAB C EE (A(A AA A '9 34439 344?B' *  BA "BA CE  &* "  B"EAA E B B(AB C AE "AABAB A);&B  AE "EB A);#B CE C "AB( "AB(BA' AB C * E E( );&  );# B * CB(BA A.B B( AE A '9 +55/H F A '9 344?B' %EAEE * BC( AE E CEAB  BE AE9 +55/H I1  AE9 3446B  B A EAB C AB E" A* A '9 344=B'  
10 E AE(AE C A GE BCE C *' * AE ( B (B (BA C CB   AD CBE(AB A "  A%  B BB' * +=4  * +?4 (AB BAB AEE' * +34 B (E A A E B (""ABBBA A2&(EB' & A"BB( (BB' 7! AEB AEAB "B( @B' EED BB(A A AA(A BA C &  A BEAB BA C 7!'
  
 
+4
 
  ;E<#*;<
 -43 2 DB5(5 ./  A B (A AA * +=4. B(  CB(BA B E BEAB AI A '9 +55=B' ; C(AE  C *. B( E  E( B B1   EA C BAE ( BEAB' )AE BEB AE(AE C "EB ( E9 E(AB B C(B(AB  E C  CBE  DE C B A *6 B""(" E C *. B( A*EE A '9 +55?B' *. B( D EBAB B C(AB C AE "' !(AE"BB( "EAE (E(AEBB  CE C "AB( "AB(BA E B"BE B *. B($ );&  );# B(AB E E BBBA B *+ AEA EBA C *. B( AF A '9 344?B'  BAB A ( C * B (("B  E( A C "(AEB9 # E("AE  *B A " AA A '9 344/B' EEB BE "A" "EB A E AA *. B( D CB(BA B "AB EB  @"EAE BE   AE B(E B BAE EB' A B  A AA *. B( E E EB  @B A DB A" B( AAE A '9 +55-H *EE A '9 3444B' @BAEA BE AEAB B *. B( (  E(  BA C EAB  "BE  =<#&; AAE A '9 +555B' ;B CBB BB(A @BAEA BE EBAB A EAB C A EABEB( A' E(A9  A  E A ' A344=B D AA * CB(B( B B( EA B "EBB BE  "ECEB  B(E CE1B AB B A AB"B AA   E( "ECE( CE (E ("AB B A (E "ECE( AA'   
  
 
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