Long-term relation between anthropometric and metabolic changes in women with a risk of the metabolic syndrome ; Moterų antropometrinių ir medžiagų apykaitos rodiklių pokyčių ilgalaikis ryšys su metabolinio sindromo rizika

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Vilnius University Jelena Volochovič LONG-TERM RELATION BETWEEN ANTHROPOMETRIC AND METABOLIC CHANGES IN WOMEN WITH A RISK OF THE METABOLIC SYNDROME Summary of Doctoral Dissertation Medical Sciences, Medicine (07B) Vilnius, 2010 Doctoral dissertation was prepared at the Faculty of Medicine of Vilnius University in 2006 – 2010. Scientific tutors: Prof Dr Janina Didžiapetrienė (Institute of Oncology of Vilnius University, Biomedical Sciences, Medicine – 07 B) 2006-2007; Prof Dr Gražina Drąsutienė (Clinic of Obstetrics-Gynaecology of the Faculty of Medicine of Vilnius University, Biomedical Sciences, Medicine – 07 B) 2007-2010 . Consultant: Prof Dr Janina Tutkuvienė, Department of Anatomy, Histology and Anthropology of the Faculty of Medicine of Vilnius University, Biomedical Sciences, Medicine – 07 B.

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Vilnius University     
  Jelena Volochovič    LONG-TERM RELATION BETWEEN ANTHROPOMETRIC AND METABOLIC CHANGES IN WOMEN WITH A RISK OF THE METABOLIC SYNDROME
Summary of Doctoral Dissertation Medical Sciences, Medicine (07B)
Vilnius, 2010
Doctoral dissertation was prepared at the Faculty of Medicine of Vilnius University in 2006 –
2010.
Scientific tutors:
Prof DrJanina Didžiapetrien(Institute of Oncology of Vilnius University, Biomedical
Sciences, Medicine – 07 B) 2006-2007;
Prof Dr GražinaDrąsutien(Clinic of Obstetrics-Gynaecology of the Faculty of Medicine of
Vilnius University, Biomedical Sciences, Medicine – 07 B) 2007-2010 .
Consultant:
Prof DrJanina Tutkuvien, Department of Anatomy, Histology and Anthropology of the
Faculty of Medicine of Vilnius University, Biomedical Sciences, Medicine – 07 B.
The dissertation is defended at the Board of the Medical Science Trend of Vilnius University:
Chairman:
Prof Habil DrAleksandras Laucevičius University, Biomedical Sciences, Medicine (Vilnius
(07B) 
Members:
Prof Habil Dr Vytautas Usonis (Vilnius University, Biomedical Sciences, Medicine (07B) 
Prof Habil DrVaidutis Kučinskas(Vilnius University, Biomedical Sciences, Biology (01B)
Assoc Prof DrDaiva Vaitkien(Lithuanian University of Health Sciences, Biomedical Sciences,
Medicine (07B)
Assoc Prof Dr Mykolas Mauricas (National Institute of Scientific Researches Centre of
Innovative Medicine, Biomedical Sciences, Biology (01B)
Oponents:
Prof DrŽaneta Petrulionien(Vilnius University, Biomedical Sciences, Medicine (07B)
Prof Dr Dainius H. Pauža (Lithuanian University of Health Sciences, Biomedical Sciences, 
Biology (01B)
The dissertation will be defended at the meeting of the Board of the Medical Science Trend of Vilnius University on the 21st of14:00, at the Clinic of Obstetrics and December 2010,
Gynaecology of Vilnius University, Antakalnio str. 57, Vilnius.
 
The summary of the dissertation was sent off on the ________ of November 2010.
The of the doctoral dissertation is available for review at Vilnius university library (Universiteto
str. 3, LT-01122, Vilnius, Lithuania)
 
 
 
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Vilniaus universitetas     
  Jelena Volochovič    MOTER ANTROPOMETRINI IR MEDŽIAG APYKAITOS RODIKLI POKYČI ILGALAIKIS RYŠYS SU METABOLINIO SINDROMO RIZIKA 
Daktaro disertacijos santrauka Medicinos mokslai, medicina (07B)
Vilnius, 2010
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Disertacija rengta Vilniaus universiteto Medicinos fakultete 2006 – 2010 metais
 
Moksliniai vadovai:
Prof. dr. Janina Didžiapetrien (Vilniaus universiteto Onkologijos institutas, biomedicinos
mokslai, medicina – 07B) 2006 – 2007 m. m.:
Prof. dr. Gražina Drąsutien (Vilniaus universitetas, biomedicinos mokslai, medicina –07B)
2007 – 2010 m. m.
Konsultantas:
Prof. dr. Janina Tutkuvien (Vilniaus universitetas, biomedicinos mokslai, medicina–07 B)
 Disertacija ginama Vilniaus universiteto Medicinos mokslo krypties taryboje:
Pirmininkas:
Prof. habil. dr. Aleksandras Laucevičius (Vilniaus universitetas,
medicina– 07B).
Nariai:
biomedicinos mokslai,
Prof. habil. dr. Vytautas Usonis (Vilniaus universitetas, biomedicinos mokslai, medicina – 07B);
Prof. habil. dr. Vaidutis Kučinskas (Vilniaus universitetas, biomedicinos mokslai, biologija –
01B);
Doc. dr. Daiva Vaitkien (Lietuvos sveikatos moksluniversitetas, biomedicinos mokslai,
medicina– 07B);
Doc. dr. Mykolas Mauricas (Valstybinio mokslinio tyrim instituto Inovatyvios medicinos
centras, biomedicinos mokslai, biologija – 01B)
Oponentai:
Prof. dr. Žaneta Petrulionien (Vilniaus universitetas, biomedicinos mokslai, medicina– 07B);
Prof. dr. Dainius Haroldas Pauža (Lietuvos sveikatos moksltesistanuvire, biomedicinos
mokslai, biologija – 01B).
Disertacija bus ginama viešame Vilniaus universiteto Medicinos krypties tarybos posdyje 2010 m. gruodžio mn. 21 d. 14.00val., Vilniaus universiteto Akušerijos ir ginekologijos klinikos
Didžiojoje auditorijoje, Antakalnio g. 57, Vilnius
 
Disertacijos santrauka išsiuntinta 2010 m. lapkričio _________ d. Disertacija galima peržirti Vilniaus universiteto bibliotekoje.     
 
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CONTENT
MOSTLY USED CONCEPTS AND ABBREVIATIONS............................................ 8
1. INTRODUCTION.................................................................................................... 10
1.1. Problem................................................................................................................ 10
1.2. Relevance and scientific newness of work.......................................................... 11
1.3. Theoretic and applicable meaning of work.......................................................... 11
2. AIM OF WORK....................................................................................................... 12
3. TASKS OF WORK.................................................................................................. 12
4. DEFENDED PROPOSITIONS ……………………………………………..…… 12
 
5. REVIEW OF LITERATURE................................................................................. 13
6. 
 
5.1. meaning for the function and pathology ofAdipose tissue –its topography and
the woman’s reproductive system....................................................................... 13
5.2. Adiposopathy....................................................................................................... 14
5.3. Adipokines........................................................................................................... 14
5.4.  17 …..Changes in the women’s body composition ……………………………….
5.4.1. Changes in the anthropometric parameters in women during
pregnancy..................................................................................................... 17
5.4.2. Changes in the anthropometric parameters in women during
perimenopause .............................................................................................. 18
5.5. Metabolic changes in women in different periods of life.................................... 19
5.5.1. Metabolic peculiarities in pregnant women............................................... 19
5.5.2. Metabolic peculiarities during perimenopause …..................................... 20
5.6. Metabolic syndrome ........................................................................................... 21
RESEARCH MATERIAL AND METHODS........................................................ 23
6.1. Research material................................................................................................. 23
6.2. Research methods................................................................................................ 23
6.2.1. Questionnaire survey................................................................................. 23
6.2.2. Anthropometric parameters ...................................................................... 23
6.2.3. Metabolic parameters................................................................................ 25
6.2.3.1. 
6.2.3.2. 
6.2.3.3. 
Lipid metabolism parameters.................................................. 26
Carbohydrate metabolism parameters...................................... 26
Adipokines metabolism parameters ........................................ 27
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6.2.4. Clinical researches..................................................................................... 27
6.2.5. Criteria of diagnostics of metabolic syndrome.......................................... 28
6.2.6. Methods of statistical analysis................................................................... 28
6.3. Ethical aspects..................................................................................................... 28
7. RESULTS.................................................................................................................. 29
8. 
 
7.1. Characteristic of the researched........................................................................... 29
7.2. Long-term changes in the women’s body............................................................ 31
7.2.1. Changes in anthropometric parameters of researched women within twenty
years.............................................................................................................. 31
7.2.2. Changes in metabolism of researched women within twenty years.......... 36
7.2.2.1. 
7.2.2.2. 
Changes in lipid metabolic parameters within twenty years ...36
Changes in glucose metabolism parameters within twenty
years....................................................................................................... 37
7.2.2.3. 
Relation between changes in anthropometric and metabolic
parameters in women and tendency to have metabolic syndrome ....... 38
7.3. Peculiarities of anthropometric and metabolic changes in healthy and metabolic
syndrome women during pregnancy and within twenty years............................ 38
7.3.1. Peculiarities of anthropometric changes in healthy and metabolic syndrome
women during pregnancy and within twenty years....................................... 39
7.3.2. changes in healthy and metabolic syndromePeculiarities of metabolism
women during pregnancy and within twenty years....................................... 47
7.3.2.1. 
Peculiarities of lipid changes in healthy and metabolic
syndrome women during pregnancy and within twenty years.............. 47
7.3.2.2. 
Peculiarities of glucose changes in healthy and metabolic
syndrome women during pregnancy and within twenty years.............. 50
7.4. Peculiarities of leptin and adiponectin metabolism in women under physiological
and pathological conditions................................................................................. 50
RESULT DISCUSSION ………………………………………………………….. 55
 
8.1. Long-term changes in the women’s body............................................................ 55
8.1.1. Changes in anthropometric parameters in researched women within twenty
years.............................................................................................................. 55
8.1.2. Metabolic changes in researched women within twenty years.................. 58
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9. 
8.2. Peculiarities of anthropometric and metabolic changes in healthy and metabolic
syndrome women during pregnancy and within twenty years............................ 59
8.3. and adiponectin concentrations in women’s bloodPeculiarities of serum leptin
under physiological and pathological conditions................................................. 63
CONCLUSIONS....................................................................................................... 66
10. LIST OF REFERENCES........................................................................................ 67
11. LIST OF PUBLICATIONS.................................................................................... 88
 
 
 
 
 
 
 
 
 
 
 
 
 
        
 
 
 
 
 
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MOSTLY USED CONCEPTS AND ABBREVIATIONS
AC –Atherogenic Coefficient
ABP –arterial blood pressure
AHA 2009 –A Joint Interim Statement of the International Diabetes Federation Task
Force on Epidemiology and Prevention; National Heart, Lung, and Blood Institute;
American Heart Association; World Heart Federation; International Atherosclerosis
Society; and International Association for the Study of Obesity recommended criteria of
diagnostics of the metabolic syndrome AHA/NHLBI –American Heart Association / National Heart, Lung, and Blood Institute
AIP –Atherogenic Index of Plasma
BMI –body mass index
Ch –cholesterol
CHD –coronary heart disease
CI - confidence interval
DM –diabetes mellitus
GDM –gestational diabetes mellitus
HDL –high-density lipoprotein
IDF 2005–The International Diabetes Federation recommended criteria of diagnostics of
the metabolic syndrome
IUGR - intrauterine growth restriction
LDL – low-density lipoprotein
LPL –lipoprotein lipase
M –mean
Max –maximal value
Min –minimal value
MS –metabolic syndrome
NCEP/ATP III 2001–Third Report of the Expert Panel on Detection, Evaluation, and
Treatment of High Blood Cholesterol in Adults /Adult Treatment Panel III recommended
criteria of diagnostics of the metabolic syndrome
Non-HDL –non-high-density lipoprotein
OGTT –oral glucose tolerance test
OR –odds ratio
 
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