Mechanisms of ammonium-induced depolarization of astrocytes in situ

Mechanisms of ammonium-induced depolarization of astrocytes in situ

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Mechanisms of ammonium-induced depolarization of astrocytes in situ Inaugural-Dissertation zur Erlangung des Doktorgrades der Mathematisch-Naturwissenschaftlichen Fakultät der Heinrich-Heine-Universität Düsseldorf vorgelegt von Jonathan Stephan aus Lüdenscheid Düsseldorf, März 2011 Aus dem Institut für Neurobiologie der Heinrich-Heine Universität Düsseldorf Gedruckt mit der Genehmigung der Mathematisch-Naturwissenschaftlichen Fakultät der Heinrich-Heine-Universität Düsseldorf Referentin: Prof. Dr. Christine R. Rose Koreferent: Prof. Dr. Dieter Willbold Tag der mündlichen Prüfung: 14.04.2011 Introductory Remarks Parts of this doctoral thesis contains results from experiments carried out with ion-sensitive microelectrodes for measuring the extracellular potassium concentration in brain tissue slices and resembles content of the following diploma theses: 1.: Haack, Nicole; February, 2010; “Influence of Ammonium on the Extracellular Potassium Homeostasis in the Hippocampus”. 2.: Koch, Daniel; February, 2011: “Mechanisms of Ammonia-induced Extracellular Potassium Changes in the Hippocampus of Mouse”. Abstract Hepatic encephalopathy (HE) is a serious neurological disorder, which is caused by acute or chronic liver failure.

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Published 01 January 2011
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Language English
Document size 19 MB
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