Nucleotide excision repair pathway modulating both cancer risk and therapy [Elektronische Ressource] / presented by Rashda Abbasi

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Dissertation submitted to the Combined Faculties for the Natural Sciences and for Mathematics of the Ruperto-Carola University of Heidelberg, Germany For the degree of Doctor of Natural Sciences Presented by M.Phil - Rashda Abbasi Born in Karachi, Pakistan Oral-examination:…………………………… I II Nucleotide excision repair pathway modulating both cancer risk and therapy Referees: Prof. Dr. Thomas Efferth PD Dr. Rajiv Kumar III IV Division: Epigenomics and Cancer Risk Factors Head of the division: Prof. Dr. Christoph Plass Deutsches Krebsforschungszentrum (DKFZ) in the Helmholtz Association Heidelberg V VI DECLARATION This thesis is a presentation of my original research work and that it has not been submitted anywhere for any award. Wherever contributions of others are involved, every effort is made to indicate this clearly, with due reference to the literature. stHeidelberg, 1 December, 2009 Rashda Abbasi VII VIII In The Name Of Allah, The Most Beneficent, The Most Merciful IX X Summary Summary Nucleotide excision repair (NER) plays a key role in repairing a wide variety of DNA damage including bulky DNA adducts caused by ultraviolet radiation and exposure to harmful substances like tobacco smoke and alcohol. Genetic variations and somatic mutations in NER genes might affect cancer risk and therapy.

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Published 01 January 2010
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Language English
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Dissertation
submitted to the
Combined Faculties for the Natural Sciences and for Mathematics
of the Ruperto-Carola University of Heidelberg, Germany


For the degree of
Doctor of Natural Sciences









Presented by
M.Phil - Rashda Abbasi
Born in Karachi, Pakistan

Oral-examination:……………………………
I
II
Nucleotide excision repair pathway modulating
both cancer risk and therapy



















Referees:
Prof. Dr. Thomas Efferth
PD Dr. Rajiv Kumar
III
IV
Division: Epigenomics and Cancer Risk Factors
Head of the division: Prof. Dr. Christoph Plass
Deutsches Krebsforschungszentrum (DKFZ) in the Helmholtz
Association
Heidelberg

V
VI DECLARATION
This thesis is a presentation of my original research work and that it
has not been submitted anywhere for any award. Wherever
contributions of others are involved, every effort is made to indicate
this clearly, with due reference to the literature.



stHeidelberg, 1 December, 2009 Rashda Abbasi
VII
VIII
In The Name Of Allah, The Most Beneficent, The Most Merciful
IX
X