Polymer-metallodrug conjugates for cancer diagnostics and therapy [Elektronische Ressource] / submitted by Nadine E. Brückmann
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Polymer-metallodrug conjugates for cancer diagnostics and therapy [Elektronische Ressource] / submitted by Nadine E. Brückmann

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Polymer-Metallodrug Conjugatesfor Cancer Diagnostics and TherapyINAUGURAL DISSERTATIONsubmitted to the faculty ofHeinrich-Heine-Universit¨at Dusseldorf¨Institut fur¨ Anorganische Chemie und StrukturchemieLehrstuhl I: Bioanorganische Chemie and Katalysein partial fulfillment of the requirements for the degree ofDr. rer. nat.submitted byNadine E. Bruc¨ kmannD¨ usseldorf, November 2010Printed with permission of theMathematisch-Naturwissenschaftliche Fakult¨atHeinrich-Heine-Universit¨at Dusseldorf¨Graduate referee: Prof. Dr. Dr. W. Kl¨auiCo-referee: Prof. Dr. C. GanterDate of graduate thesis defense: 13.01.2011IPresentations, Publications and Awards:Presentations (talks and posters):¨Nadine E. Bruckmann, Peter C. Kunz, New Polymer-Metallodrug Conjugates forthCancer Diagnostics,2008,XI InternationalSeminarforPh.D.StudentsonOrganometal-lic and Coordination Chemistry, Sayda, Germany.¨Peter C. Kunz, Nadine E. Bruckmann, Bioorganometallics going Polymer: Usingththe EPR-Effect for Organometallic Drug Targeting,2008,XI SymposiumonMedicinalOrganometallic Chemistry, St. Martin in der Pfalz, Germany.¨Nadine E. Bruckmann, Peter C. Kunz, Hunting for Tumours with FluorescentthPolymers, 2009,11 JCF - Spring Symposium, Essen, Germany.¨Nadine E. Bruckmann, Peter C. Kunz, Fluorescent Polymers for Tumour Diag-thnostics, 2010,ISBOMC10-5 International Symposium on Bioorganometallic Chem-istry, Ruhr-Universit¨at Bochum, Germany.Publications:¨Peter C. Kunz, Nadine E.

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Published 01 January 2010
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Polymer-Metallodrug Conjugates
for Cancer Diagnostics and Therapy
INAUGURAL DISSERTATION
submitted to the faculty of
Heinrich-Heine-Universit¨at Dusseldorf¨
Institut fur¨ Anorganische Chemie und Strukturchemie
Lehrstuhl I: Bioanorganische Chemie and Katalyse
in partial fulfillment of the requirements for the degree of
Dr. rer. nat.
submitted by
Nadine E. Bruc¨ kmann
D¨ usseldorf, November 2010Printed with permission of the
Mathematisch-Naturwissenschaftliche Fakult¨at
Heinrich-Heine-Universit¨at Dusseldorf¨
Graduate referee: Prof. Dr. Dr. W. Kl¨aui
Co-referee: Prof. Dr. C. Ganter
Date of graduate thesis defense: 13.01.2011
IPresentations, Publications and Awards:
Presentations (talks and posters):
¨Nadine E. Bruckmann, Peter C. Kunz, New Polymer-Metallodrug Conjugates for
thCancer Diagnostics,2008,XI InternationalSeminarforPh.D.StudentsonOrganometal-
lic and Coordination Chemistry, Sayda, Germany.
¨Peter C. Kunz, Nadine E. Bruckmann, Bioorganometallics going Polymer: Using
ththe EPR-Effect for Organometallic Drug Targeting,2008,XI SymposiumonMedicinal
Organometallic Chemistry, St. Martin in der Pfalz, Germany.
¨Nadine E. Bruckmann, Peter C. Kunz, Hunting for Tumours with Fluorescent
thPolymers, 2009,11 JCF - Spring Symposium, Essen, Germany.
¨Nadine E. Bruckmann, Peter C. Kunz, Fluorescent Polymers for Tumour Diag-
thnostics, 2010,ISBOMC10-5 International Symposium on Bioorganometallic Chem-
istry, Ruhr-Universit¨at Bochum, Germany.
Publications:
¨Peter C. Kunz, Nadine E. Bruckmann, and Bernhard Spingler, Towards
Polymer Diagnostic Agents - Copolymers of N-(2-Hydroxypropyl)-methacrylamide and
Bis(2-pyridylmethyl)-4-vinylbenzylamine: Synthesis, CharacterisationandRe(CO) -Labelling,
3
Eur. J. Inorg. Chem., 2007, 394-399.
¨Peter C. Kunz, Michael Berghahn, Nadine E. Bruckmann, Marcus Dick-
meis, Markus Kettel and Bernhard Spingler,FunctionalisedTris(pyrazolyl)methane
Ligands and Re(CO) Complexes Thereof, Z. Anorg. Allg. Chem., 2009, 635, 471-478.
3
¨ ¨Nadine E. Bruckmann, Susanne Kogel, Alexandra Hamacher, Matthias
U. Kassack and Peter C. Kunz, Fluorescent Polylactides with Rhenium(bisimine)-
cores for Tumour Diagnostics, Eur. J. Inorg. Chem., 2010, in press.
Awards:
th1st poster prize (Hunting for Tumours with Fluorescent Polymers, 2009,11 JCF -
Spring Symposium)
3rd poster prize (Fluorescent Polymers for Tumour Diagnostics, 2010, ISBOMC 10)
IIIIITo my beautiful daughter Celine,
may her world always be one of curiosity and wonder
IVVAcknowledgments
It has been a pleasure working with the faculty, staff and students at the Institute of
InorganicChemistryIduringmytenureasadoctoralstudent. MythanksgotoProfessor
Dr. Dr. Wolfgang Kl¨aui for the freedom I was given to pursue my research interests and
to Dr. Peter Kunz, my long-time advisor and friend for mentoring and advice. Thanks
also go to Prof. Dr. Christian Ganter for taking the time to evaluate this dissertation
as the co-referee.
Many thanks to my fellow (former) doctoral students Steffen Alfs, Melanie Bongartz,
Wilhelm Huber, Arndt Karschin, Dr. Monika Lindner, Mareike Meyer and Corinna
Wetzel, graduate student Anna Louisa Noffke, as well as Dr. Udo Beckmann, who made
thesometimestediousresearchalotoffunbyofferingtheirhelpandadviceandgenerally
creating a wonderful work environment.
Furthermore, I owe my thanks to the staff of the analytical services, Peter Behm
(NMR), Dr. Peter Tommes and Ralf Burgel¨ (mass spectrometry), Dietmar Frunzke
(IR spectroscopy), as well as to Dr. Stefanie Weidtkamp-Peters (confocal fluorescence
microscopy) from the Institute of Molecular Physical Chemistry, Patricia Bach (GPC
analysis) and Bernd Muller¨ (DLS) from the Institute of Organic Chemistry and Macro-
molecularChemistry,aswellasDenisD¨orr(flourescencespectroscopy)fromtheInstitute
of Physical Chemistry and Electrochemistry II. For experimental help I thank DAAD
exchange student Matthew Merriman, who spent two months in Germany working on
rhenium lactide conjugates.
Invaluable for all things concerning cell cultures and microbiology was the cooperation
with the Department of Pharmacological Chemistry: Prof. Dr. Matthias U. Kassack,
Dr. Alexandra Hamacher, Susanne K¨ogel and Daniel Esser.
And finally, without the constant encouragement, support and unshattering belief in me,
given selflessly by my family and friends, I would not be where I am today. You know
who you are. Thank you.
VIVII”The greatest compliment that was ever paid me was when one asked me
what I thought, and attended to my answer. I am surprised, as well as
delighted, when this happens, it is such a rare use he would make of me, as
if he were acquainted with the tool.” - Henry David Thoreau
VIIIIX