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Qualitative and quantitative investigation of the cytogenetic effects of densely ionizing radiation in vitro and in vivo [Elektronische Ressource] / von Carola Hartel

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Qualitative and quantitativeinvestigation of the cytogenetice ects of densely ionizingradiation in vitro and in vivoVom Fachbereich Physikder Technischen Universit at Darmstadtzur Erlangung des Gradeseines Doktors der Naturwissenschaften(Dr. rer. nat.)genehmigte Dissertation vonDipl.-Phys. Carola Hartelaus Frankfurt am MainDarmstadt 2010D17Referent: Prof. Dr. M. DuranteKorreferent: Prof. Dr. Dr. h.c. G. KraftTag der Einreichung: 9.2.2010Tag der Prufung: 12.5.2010AbstractThe purpose of this work was to compare the cytogenetic e ects of denselyand sparsely ionizing radiations in vitro and in vivo. To achieve this, chromo-somal aberrations in peripheral blood lymphocytes were exposed in vitro todi erent doses of X-rays and C-ions with di erent energies; furthermore, lym-phocytes were obtained from prostate-cancer patients before, during and afterradiotherapy and analyzed using the multiplex uorescence in situ hybridiza-tion (mFISH) technique. These cancer patients were either treated with C-ionboost irradiation in the course of a conventional photon intensity-modulatedradiotherapy (IMRT) or solely with IMRT. Blood samples were taken fromeach patient before, during, at the end of and one year after the therapy.

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Published 01 January 2010
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Language English
Document size 8 MB