The focal adhesion protein zyxin mediates wall tension-induced signalling in vascular cells [Elektronische Ressource] / presented by Agnieszka Wójtowicz

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Dissertation submitted to the Combined Faculties for the Natural Sciences and for Mathematics of the Ruperto-Carola University of Heidelberg, Germany for the degree of Doctor of Natural Sciences The focal adhesion protein zyxin mediates wall tension-induced signalling in vascular cells Presented by Diplom – Biotechnologist Agnieszka Wójtowicz born in: Wrocław, Poland Oral-examination: Heidelberg 2008 0 ............................................... ............................................... ............................................... Referees: Prof. Dr. F. Wieland Prof. Dr. M. Hecker 1 CONTENTS CONTENTS ABBREVIATIONS V 1. INTRODUCTION 1 1.1 Wall tension…………………………………………………………. 1 1.2 Vascular mechanotransduction……………………………………… 4 1.3 Zyxin in vascular mechanotransduction…………………………….. 5 1.4 Wall tension-induced gene expression…………................................. 7 1.5 The role of natriuretic peptides in cardiac and vascular remodelling.. 8 1.6 Aims of the study……………………………………………………. 11 2. MATERIALS 12 2.1 Synthetic oligonucleotide primers for PCR………………………… 12 2.2 Bacterial strains and plasmids………………………………………. 13 2.3 Small interfering RNA (siRNA)……………………………………. 13 2.4 Antibodies…………………………………………………………... 14 2.5 Cell culture………………………………………………………….. 15 2.6 Mouse strains……………………………………………………….. 15 2.

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Published 01 January 2008
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Language English
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