Treating Premature Ejaculation: Dapoxetine Hydrochloride Powder

Treating Premature Ejaculation: Dapoxetine Hydrochloride Powder

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http://www.aasraw.com/products/dapoxetine-hydrochloride/ - Dapoxetine hydrochloride powder also write as  dapoxetine HCL powder, it is hydrochloride type of dapoxetine. is white crystaline powder.

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Published 19 April 2018
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Treating Premature Ejaculation : Dapoxetine hydrochloride powder
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Content
1. What is Dapoxetine hydrodhloride powder? ........................................ 1
2. How does Dapoxetine hydrochloride work?......................................... 5
3. Dapoxetine hydrochloride other name................................................. 6
4. What is Dapoxetine hydrochloride use for? ......................................... 6
5. What is Premature Ejaculation(PE)? ..................................................... 7
6. How to use Dapoxetine hydrochloride powder8Dapoxetine dosage
7. Dapoxetine hydrochloride effects? ..................................................... 10
8. Dapoxetine VS Tadalafil ...................................................................... 12
9. Is it safe to take dapoxetine hydrochloride?....................................... 15
10. Dapoxetine side effects..................................................................... 18
11. Buy Dapoxetine hydrochloride powder ............................................ 19
1. What is Dapoxetine hydrodhloride powder?
Dapoxetine hydrochloride powder also write asdapoxetine HCL powder, it
is hydrochloride type of dapoxetine. Dapoxetine hydrochloride powder is
Treating Premature Ejaculation : Dapoxetine hydrochloride powder
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white crystaline powder, CAS No. is 129938-20-1. Dapoxetine HCL powder
is a new antidepressant, has been found to be safe and effective for the
treatment of premature ejaculation, according to two major clinical trials.
Dapoxetin is a short-acting selective serotonin reuptake inhibitor (SSRI). It is
not uncommon for SSRIs to be used off-label for premature ejaculation.
Premature ejaculation(PE) is the most common male sexual dysfunction with
a prevalence of between 20% and 40%. Recently, the International Society for
Sexual Medicine has proposed the following evidence-based definition:“PE is
a male sexual dysfunction characterized by ejaculation that always or nearly
always occurs prior to or within about 1 minute of vaginal penetration;
inability to delay ejaculation on all or nearly all vaginal penetrations; and
negative personal consequences, such as distress, bother, frustration, and/or
the avoidance of sexual intimacy". In addition, PE affects numerous aspects of
a man's life, including sexual confidence, interpersonal relationships, and the
sexual satisfaction of both partners. The role of PE on the individual and the
sexual relationship is very significant. Thus, it is important to treat patients
with Premature ejaculation(PE) in order to improve quality of life. At present,
Treating Premature Ejaculation : Dapoxetine hydrochloride powder
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treatment of PE includes mainly psychotherapy, drug therapy, and surgical
treatment6.
Drug therapy is not only likely to be the most receptive approach for patients,
but it is also the most commonly used method. Selective serotonin reuptake
inhibitors (SSRIs) have become the most widely used medicine in the world.
Dapoxetine hydrochloride, belonging to the class of SSRIs, was the first drug
originally approved for the on-demand treatment of men with PE by seven
European countries in 2008.
Name
CAS
Molecular Formula
Molecular Weight
Melt Point
Storage Temp
Color
Decription
Dapoxetine powder description
Dapoxetine hydrochloride, Dapoxetine hydrochloride
129938-20-1
C9H7ClN2O5
258.62
175-179°C
-20°C Freezer
White crystalline powder
Dapoxetine HCL is a short-acting novel selective serotonin reuptake inhibitor, used for the treatment of premature ejaculation.Dapoxetine not only reduces the peak amplitude of Kv4.3 currents but also accelerates the decay rate of current inactivation in a concentration-dependent manner. Dapoxetine decreases the integral of the Kv4.3 currents over the duration of a depolarizing pulse with an IC50 of 5.3 μM. Dapoxetine also causes a substantial acceleration in
Treating Premature Ejaculation : Dapoxetine hydrochloride powder
www.aasraw.comaas15@aasraw.com, Whatsapp:+8618902484839 closed-state inactivation. Dapoxetine produces a significant use-dependent block, which is accompanied by a delayed recovery from inactivation of Kv4.3
Package method
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currents. Dapoxetine decreases the peak amplitude of
Kv1.5 currents and accelerates the decay rate of current
inactivation in a concentration-dependent manner with
an IC50 of 11.6 μM. Dapoxetine decreases the tail
current amplitude and slows the deactivation process
of Kv1.5, which results in a tail crossover phenomenon. Dapoxetine produces a use-dependent block of Kv1.5 at frequencies of 1 and 2 Hz and slowed the time
course for recovery of inactivation.Dapoxetine also
appears to be a useful adjunct to morphine, lowering the threshold for analgesia, although Dapoxetine itself has negligible analgesic activity. Dapoxetine is the
D-enantiomer of LY 243917 and is 3.5 times more potent as a serotonin reuptake inhibitor than the L-enantiomer
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Treating Premature Ejaculation : Dapoxetine hydrochloride powder
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2. How does Dapoxetine hydrochloride work?
Dapoxetine mechanism of action? The mechanism through which dapoxetine
affects premature ejaculation is still unclear. However, it is presumed that
dapoxetine works by inhibiting serotonin transporter and subsequently
increasing serotonin's action at pre and postsynaptic receptors Human
ejaculation is regulated by various areas in the central nervous system
(CNS).The ejaculatory pathway originates from spinal reflex at the
thoracolumbar and lumbosacral level of spinal cord activated by stimuli from
male genital. These signals are relayed to the brain stem, which then is
influenced by a number of nuclei in the brain such as medial preoptic and
paraventricular nulcei.Clement's study performed on anaesthetized male rats
showed that acute administration of dapoxetine inhibits ejaculatory
expulsion reflex at supraspinal level by modulating activity of lateral
paragigantocellular nucleus (LPGi) neurons. These effects cause an increase in
pudendal motoneuron reflex discharge (PMRD) latency. However, it is unclear
whether dapoxetine acts directly on LPGi or on the descending pathway in
which LPGi located.
Treating Premature Ejaculation : Dapoxetine hydrochloride powder
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3. Dapoxetine hydrochloride other name
Dapoxetine hydrochloride/Dapoxetine HCL marketed as Priligy and
Westoxetin, among and other brands.
4. What is Dapoxetine hydrochloride use for?
Dapoxetine hydrochloride powder/Dapoxetine HCL powder use for treat
premature ejaculation in men aged 18 to 64 years.
Priligy tablets contain the active ingredient raw dapoxetine hydrochloride
powder, which is a type of medicine known as a selective serotonin reuptake
inhibitor. It is used to treat premature ejaculation in men.
Raw dapoxetine hydrochloride powderworks by increasing the activity of
serotonin in the nervous system. Serotonin is a neurotransmitter that is
involved in passing messages between nerve cells. It has various functions in
the body and is involved in sending the nerve messages that result in
ejaculation. Increasing the activity of serotonin in the nervous system helps to
increase the time it takes to ejaculate and improve control over the
ejaculation.The medicine is taken a couple of hours before you intend to have
sex to help you last longer before you climax.
Treating Premature Ejaculation : Dapoxetine hydrochloride powder
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The research team examined the results of two trials, totalling 2,614 men. All
the men had from moderate to severe premature ejaculation - on average,
the men were ejaculating within one minute of penetration. Half of them
were randomly selected to receive Dapoxetine while the other half received a
placebo. Both groups had to take their medication from 1 to 3 hours before
sexual intercourse.
After three months, the men taking a 30-milligram dose of dapoxetine took
an average 2.78 minutes to ejaculate after penetration, those on a
60-milligram dose took 3.32 minutes. The placebo group averaged 1.75
minutes (after three months).
5. What is Premature Ejaculation(PE)?
In lay terms it means 'coming too quickly' (for a man). The man ejaculates
sooner than he or his partner would like. It is common for this to happen now
and again. It is seen as a problem for many men and some of their partners
if this happens regularly. It is the most common male sexual dysfuntion -
estimated to affect about 20% of males in the USA aged 18-59.
Treating Premature Ejaculation : Dapoxetine hydrochloride powder
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The problem is thought to be psychological. However, it can also be
biological.
Premature ejaculation has two classifications:
Primary Premature Ejaculation
The man has experienced premature ejaculation throughout his sexually
active life.
Secondary Premature Ejaculation
The condition has developed after the man used to have satisfying sex
without ejaculatory problems.
6. How to use Dapoxetine hydrochloride powder Dapoxet
ine dosage
Dapoxetine hydrochloride powder for saleonline also, the makers buy
dapoxetine hydrochloride powder for sale online, then mix it and make into
dapoxetine tablets or other products. How to use dapoxetine?Dapoxetine
dosage?
Treating Premature Ejaculation : Dapoxetine hydrochloride powder
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-One dapoxetine tablet should be taken one to three hours before sexual
activity.
-The dapoxetine tablet can be taken either with or without food. It should be
swallowed whole to avoid getting a bitter taste from the tablet. The
dapoxetine tablet should be taken with a full glass of water.
-Dapoxetine tablet should not be taken more than once every 24 hours. It
should only be taken when sexual activity is anticipated and is not intended
as a regular treatment that is taken each day.
-The recommendeddapoxetine dosageis 30mg(dapoxetine 30mg). If this is
not effective enough your doctor may increase your dapoxetine dosage to
60mg(dapoxetine 60mg), but this should only be done if you have not
experienced any side effects with the lower dose.
-Your doctor will discuss your treatment with you after four weeks or six
dapoxetine dosage of treatment. If treatment with dapoxetine is continued
your doctor will need to see you every six months.
Dapoxetine dosage: dapoxetine 30mg and dapoxetine 60mg
Treating Premature Ejaculation : Dapoxetine hydrochloride powder
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7. Dapoxetine hydrochloride effects?
How long does dapoxetine last? What are dapoxetine hydrochloride
effects? The following summary data are taken from the article Dapoxetine: a
new option in the medical management of premature ejaculation McMahon,
Chris G, Ther Adv Urol. 2012 October; 4(5): 233-251, where the author
presents information and results of clinical trials of dapoxetine. We
encourage physicians and patients to read the entire document dapoxetine
research.
The most comprehensive results from this work comes from the Phase III
studies that included 6,081 subjects ranging in age from 18-82. In a
double-blind study, each of roughly one-third of patients received one of the
following dapoxetine doage: dapoxetine 30mg, dapoxetine 60 mg, or a
placebo.
Effects of Dapoxetine on IELT
Inter-Vaginal Latency Time
For men with an average baseline IELT of 0.9 minutes, the average IELT
Treating Premature Ejaculation : Dapoxetine hydrochloride powder
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improved to 3.1 minutes for a 30mg dose and 3.6 minutes for a 60 mg dose.
Patients taking the placebo improved to 1.9 minutes.
Ejaculation-Related Sexual Satisfaction
% Good/Very Good Ejaculatory Control
The first of the subjective scores is the subject's feeling of having ejaculatory
control. The per cent of subjects that believed that they had"good" or "very
good" control is shown in this chart.